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Maker AV, Prabhakar B, Pardiwala K. The Potential of Intralesional Rose Bengal to Stimulate T-Cell Mediated Anti-Tumor Responses. J Clin Cell Immunol. 2015;6(4)doi: 10.4172/2155-9899.1000343.
Maker, A. V., Prabhakar, B., & Pardiwala, K. (2015). The Potential of Intralesional Rose Bengal to Stimulate T-Cell Mediated Anti-Tumor Responses. Journal of clinical & cellular immunology, 6(4), . https://doi.org/10.4172/2155-9899.1000343
Maker, Ajay V, et al. "The Potential of Intralesional Rose Bengal to Stimulate T-Cell Mediated Anti-Tumor Responses." Journal of clinical & cellular immunology vol. 6,4 (2015). doi: https://doi.org/10.4172/2155-9899.1000343
Maker AV, Prabhakar B, Pardiwala K. The Potential of Intralesional Rose Bengal to Stimulate T-Cell Mediated Anti-Tumor Responses. J Clin Cell Immunol. 2015 Aug;6(4). doi: 10.4172/2155-9899.1000343. Epub 2015 Jul 22. PMID: 26618054; PMCID: PMC4662376.
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J Clin Cell Immunol. 2015 Aug;6(4). doi: 10.4172/2155-9899.1000343. Epub 2015 Jul 22.

The Potential of Intralesional Rose Bengal to Stimulate T-Cell Mediated Anti-Tumor Responses.

Journal of clinical & cellular immunology

Ajay V Maker, Bellur Prabhakar, Krunal Pardiwala

Affiliations

  1. Division of Surgical Oncology, Department of Surgery, University of Illinois at Chicago, Chicago Illinois, USA ; Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago Illinois, USA.
  2. Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago Illinois, USA.
  3. Division of Surgical Oncology, Department of Surgery, University of Illinois at Chicago, Chicago Illinois, USA.

PMID: 26618054 PMCID: PMC4662376 DOI: 10.4172/2155-9899.1000343

Abstract

Rose Bengal (RB) is a red synthetic dye that was initially used in the garment industry and has been used safely for decades as a corneal stain by ophthalmologists. Antineoplastic properties of RB have also been observed, though the mechanism of action remained to be elucidated. Recently, interest in RB as a therapeutic cancer treatment has increased due to significant anti-tumor responses with direct tumor injection in human clinical trials for metastatic melanoma. In these patients, there has been the implication that RB may mount a T-cell mediated anti-tumor response and impart antigen-specific responses in distant bystander lesions. This article serves to evaluate the potential of intralesional rose bengal to stimulate T-cell mediated anti-tumor responses in in-vitro, pre-clinical, and clinical studies.

Keywords: PV10; Rose bengal; T-cell mediated anti-tumor responses; metastatic melanoma

References

  1. Proc Soc Exp Biol Med. 1960 Aug-Sep;104:650-3 - PubMed
  2. Biomedicine. 1979 Oct;30(4):211-5 - PubMed
  3. AMA Arch Ophthalmol. 1951 Apr;45(4):419-24 - PubMed
  4. J Immunotoxicol. 2014 Oct;11(4):367-75 - PubMed
  5. Ann Surg Oncol. 2015 Jul;22(7):2135-42 - PubMed
  6. Melanoma Res. 2008 Dec;18(6):405-11 - PubMed
  7. J Surg Oncol. 2014 Mar;109(4):314-9 - PubMed
  8. Med J Aust. 1951 Nov 24;2(21):708-9 - PubMed
  9. Arch Ophthalmol. 1976 Nov;94(11):1899-1902 - PubMed
  10. PLoS One. 2013 Jul 17;8(7):e68561 - PubMed
  11. Int J Physiol Pathophysiol Pharmacol. 2012;4(2):99-107 - PubMed
  12. J Natl Cancer Inst. 1986 Jul;77(1):277-81 - PubMed
  13. ANZ J Surg. 2013 Jan;83(1-2):93 - PubMed

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