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Harab RC, Mourão PA. Increase of chondroitin 4-sulfate concentration in the endochondral ossification cartilage of normal dogs. Biochim Biophys Acta. 1989;992(2):237-40doi: 10.1016/0304-4165(89)90016-0.
Harab, R. C., & Mourão, P. A. (1989). Increase of chondroitin 4-sulfate concentration in the endochondral ossification cartilage of normal dogs. Biochimica et biophysica acta, 992(2), 237-40. https://doi.org/10.1016/0304-4165(89)90016-0
Harab, R C, and Mourão, P A. "Increase of chondroitin 4-sulfate concentration in the endochondral ossification cartilage of normal dogs." Biochimica et biophysica acta vol. 992,2 (1989): 237-40. doi: https://doi.org/10.1016/0304-4165(89)90016-0
Harab RC, Mourão PA. Increase of chondroitin 4-sulfate concentration in the endochondral ossification cartilage of normal dogs. Biochim Biophys Acta. 1989 Aug 18;992(2):237-40. doi: 10.1016/0304-4165(89)90016-0. PMID: 2503043.
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Elsevier Science

Biochim Biophys Acta. 1989 Aug 18;992(2):237-40. doi: 10.1016/0304-4165(89)90016-0.

Increase of chondroitin 4-sulfate concentration in the endochondral ossification cartilage of normal dogs.

Biochimica et biophysica acta

R C Harab, P A Mourão

Affiliations

  1. Departamento de Bioquímica, Universidade Federal do Rio de Janeiro, Brasil.

PMID: 2503043 DOI: 10.1016/0304-4165(89)90016-0

Abstract

The absolute concentrations of chondroitin 4- and 6-sulfate are compared in articular and endochondral ossification cartilage from normal dogs. In newborn dogs, the absolute concentration of chondroitin 4-sulfate decreases nearly 3-fold from the deeper endochondral ossification cartilage to the articular surface, whereas that of chondroitin 6-sulfate does not change. In cartilage from the articular surface of the epiphysis in adults, where the ossification process is complete, the concentration of chondroitin 4-sulfate is also low. These observations suggest that chondroitin 4-sulfate may be important in the ossification process. The pathogenesis of heritable disorders involving the sulfation of chondroitin sulfate is discussed in view of these findings.

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