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Alberto G, Erickson T, Popiel R, et al. Central nervous system manifestations of a valproic acid overdose responsive to naloxone. Ann Emerg Med. 1989;18(8):889-91doi: 10.1016/s0196-0644(89)80220-3.
Alberto, G., Erickson, T., Popiel, R., Narayanan, M., & Hryhorczuk, D. (1989). Central nervous system manifestations of a valproic acid overdose responsive to naloxone. Annals of emergency medicine, 18(8), 889-91. https://doi.org/10.1016/s0196-0644(89)80220-3
Alberto, G, et al. "Central nervous system manifestations of a valproic acid overdose responsive to naloxone." Annals of emergency medicine vol. 18,8 (1989): 889-91. doi: https://doi.org/10.1016/s0196-0644(89)80220-3
Alberto G, Erickson T, Popiel R, Narayanan M, Hryhorczuk D. Central nervous system manifestations of a valproic acid overdose responsive to naloxone. Ann Emerg Med. 1989 Aug;18(8):889-91. doi: 10.1016/s0196-0644(89)80220-3. PMID: 2502939.
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Ann Emerg Med. 1989 Aug;18(8):889-91. doi: 10.1016/s0196-0644(89)80220-3.

Central nervous system manifestations of a valproic acid overdose responsive to naloxone.

Annals of emergency medicine

G Alberto, T Erickson, R Popiel, M Narayanan, D Hryhorczuk

Affiliations

  1. Department of Emergency Medicine, Cook County Hospital, Chicago, Illinois 60612.

PMID: 2502939 DOI: 10.1016/s0196-0644(89)80220-3

Abstract

We report the case of a 22-year-old man who presented with a depressed level of consciousness after ingesting valproic acid. He responded to IV naloxone; over a nine-hour period, his serum valproic acid level decreased from 180.4 to 59.2 micrograms/ml with multiple-dose charcoal therapy. We recommend the use of both agents in the treatment of valproic acid overdose.

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