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Elsevier Science

Biochem Biophys Res Commun. 1985 Aug 30;131(1):58-63. doi: 10.1016/0006-291x(85)91769-3.

The formation at 37 C of a nondissociable receptor-estradiol complex.

Biochemical and biophysical research communications

J H Fishman, J Fishman

PMID: 2412556 DOI: 10.1016/0006-291x(85)91769-3

Abstract

The receptor-estradiol complex formed in rat uterine cytosol when heated at 37 C converts from a dissociable to a nondissociable form. The conversion is best observed in cytosols pretreated with charcoal at 0 C which renders the subsequently formed receptor-estradiol complexes thermostable at 37 C. In the presence of dithiothreitol the heated complex remains dissociable. Tamoxifen does not form nondissociable complexes with the estradiol receptor. It is proposed that the nondissociable form of the receptor complex is a required phase in the mechanism of estradiol action.

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