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Da Silva Machado FR, Assem ES, Ezeamuzie CI. Cardiac anaphylaxis: the role of different mediators. Part I: Histamine. Allergol Immunopathol (Madr). 1985;13(3):259-72
Da Silva Machado, F. R., Assem, E. S., & Ezeamuzie, C. I. (1985). Cardiac anaphylaxis: the role of different mediators. Part I: Histamine. Allergologia et immunopathologia, 13(3), 259-72.
Da Silva Machado, F R, et al. "Cardiac anaphylaxis: the role of different mediators. Part I: Histamine." Allergologia et immunopathologia vol. 13,3 (1985): 259-72.
Da Silva Machado FR, Assem ES, Ezeamuzie CI. Cardiac anaphylaxis: the role of different mediators. Part I: Histamine. Allergol Immunopathol (Madr). 1985 May-Jun;13(3):259-72. PMID: 2412425.
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Allergol Immunopathol (Madr). 1985 May-Jun;13(3):259-72.

Cardiac anaphylaxis: the role of different mediators. Part I: Histamine.

Allergologia et immunopathologia

F R Da Silva Machado, E S Assem, C I Ezeamuzie

PMID: 2412425

Abstract

The main objective of this paper is to review the literature and to present experimental evidence concerning the mediators involved in immediate hypersensitivity reactions in the heart, that is in Cardiac Anaphylaxis. In Part I, the evidence for allergic reactions occurring in the heart is briefly presented. The evidence for the role of histamine as a mediator of some of the manifestations of cardiac anaphylaxis is reviewed. These effects of histamine include a positive chronotropic effect and arrhythmias, both positive and negative inotropic effects and negative dromotropic responses, which are mediated by both classes of histamine receptors.

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