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Soll AH, Toomey M. Beta-adrenergic and prostanoid inhibition of canine fundic mucosal mast cells. Am J Physiol. 1989;256(4):G727-32doi: 10.1152/ajpgi.1989.256.4.G727.
Soll, A. H., & Toomey, M. (1989). Beta-adrenergic and prostanoid inhibition of canine fundic mucosal mast cells. The American journal of physiology, 256(4), G727-32. https://doi.org/10.1152/ajpgi.1989.256.4.G727
Soll, A H, and Toomey, M. "Beta-adrenergic and prostanoid inhibition of canine fundic mucosal mast cells." The American journal of physiology vol. 256,4 (1989): G727-32. doi: https://doi.org/10.1152/ajpgi.1989.256.4.G727
Soll AH, Toomey M. Beta-adrenergic and prostanoid inhibition of canine fundic mucosal mast cells. Am J Physiol. 1989 Apr;256(4):G727-32. doi: 10.1152/ajpgi.1989.256.4.G727. PMID: 2468293.
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Am J Physiol. 1989 Apr;256(4):G727-32. doi: 10.1152/ajpgi.1989.256.4.G727.

Beta-adrenergic and prostanoid inhibition of canine fundic mucosal mast cells.

The American journal of physiology

A H Soll, M Toomey

Affiliations

  1. Center for Ulcer Research and Education, Veterans Administration Wadsworth Hospital Center, Los Angeles, California.

PMID: 2468293 DOI: 10.1152/ajpgi.1989.256.4.G727

Abstract

We examined regulation of histamine release from canine hepatic and fundic mucosal mast cells in short-term culture. We found that beta- but not alpha-adrenergic agonists markedly inhibited concanavalin A (ConA)-stimulated histamine release. Inhibition by epinephrine was reversed by the beta-antagonist propranolol, but not by the alpha-adrenergic antagonists phentolamine or yohimbine. The beta 2-selective antagonist ICI 115881 reversed the effects of epinephrine, whereas the beta 1-antagonists practolol and betaxolol had little effect. Prostaglandin E2 (PGE2), but not its analogue enprostil, inhibited ConA-stimulated histamine release. This difference may relate to the ability of PGE2, but not enprostil, to stimulate adenosine 3',5'-cyclic monophosphate (cAMP) production. Forskolin, cAMP analogues, and the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine also effectively inhibited ConA-stimulated histamine release. Neither adrenergic agonists nor PGE2 inhibited histamine release stimulated by the combination of phorbol 12-myristate-13-acetate plus the calcium ionophore A23187. These data suggest that inhibition was mediated via cAMP-dependent mechanisms and was exerted on primary cell activation, rather than on postreceptor activating events.

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