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Westin S, Ström A, Gustafsson JA, et al. Growth hormone regulation of the cytochrome P-450IIC subfamily in the rat: inductive, repressive, and transcriptional effects on P-450f (IIC7) and P-450PB1 (IIC6) gene expression. Mol Pharmacol. 1990;38(2):192-7
Westin, S., Ström, A., Gustafsson, J. A., & Zaphiropoulos, P. G. (1990). Growth hormone regulation of the cytochrome P-450IIC subfamily in the rat: inductive, repressive, and transcriptional effects on P-450f (IIC7) and P-450PB1 (IIC6) gene expression. Molecular pharmacology, 38(2), 192-7.
Westin, S, et al. "Growth hormone regulation of the cytochrome P-450IIC subfamily in the rat: inductive, repressive, and transcriptional effects on P-450f (IIC7) and P-450PB1 (IIC6) gene expression." Molecular pharmacology vol. 38,2 (1990): 192-7.
Westin S, Ström A, Gustafsson JA, Zaphiropoulos PG. Growth hormone regulation of the cytochrome P-450IIC subfamily in the rat: inductive, repressive, and transcriptional effects on P-450f (IIC7) and P-450PB1 (IIC6) gene expression. Mol Pharmacol. 1990 Aug;38(2):192-7. PMID: 2385231.
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Mol Pharmacol. 1990 Aug;38(2):192-7.

Growth hormone regulation of the cytochrome P-450IIC subfamily in the rat: inductive, repressive, and transcriptional effects on P-450f (IIC7) and P-450PB1 (IIC6) gene expression.

Molecular pharmacology

S Westin, A Ström, J A Gustafsson, P G Zaphiropoulos

Affiliations

  1. Department of Medical Nutrition, Huddinge University Hospital, Karolinska Institute, Sweden.

PMID: 2385231

Abstract

The effects of growth hormone (GH) on two constitutively expressed rat liver cytochrome P-450 (P-450) enzymes, namely P-450f (IIC7) and P-450PB1 (IIC6), have been investigated. Hypophysectomy of both male and female rats results in low expression of P-450f. Single daily injections of GH cannot restore expression of P-450f but further repress it. Continuous administration of GH, on the other hand, increases expression of P-450f to levels comparable to those of the normal male and female rat. P-450PB1 is minimally affected by hypophysectomy or GH treatment, although a weak but significant repression by continuous administration of GH can be detected. Run-on analysis shows that continuous GH treatment increases transcription of P-450f. In addition, the sequence of the 5' flanking region of this gene reveals DNA segments that might have a putative role in the transcriptional regulation of P-450f by GH.

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