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Rosenspire KC, Haka MS, Van Dort ME, et al. Synthesis and preliminary evaluation of carbon-11-meta-hydroxyephedrine: a false transmitter agent for heart neuronal imaging. J Nucl Med. 1990;31(8):1328-34
Rosenspire, K. C., Haka, M. S., Van Dort, M. E., Jewett, D. M., Gildersleeve, D. L., Schwaiger, M., & Wieland, D. M. (1990). Synthesis and preliminary evaluation of carbon-11-meta-hydroxyephedrine: a false transmitter agent for heart neuronal imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 31(8), 1328-34.
Rosenspire, K C, et al. "Synthesis and preliminary evaluation of carbon-11-meta-hydroxyephedrine: a false transmitter agent for heart neuronal imaging." Journal of nuclear medicine : official publication, Society of Nuclear Medicine vol. 31,8 (1990): 1328-34.
Rosenspire KC, Haka MS, Van Dort ME, Jewett DM, Gildersleeve DL, Schwaiger M, Wieland DM. Synthesis and preliminary evaluation of carbon-11-meta-hydroxyephedrine: a false transmitter agent for heart neuronal imaging. J Nucl Med. 1990 Aug;31(8):1328-34. PMID: 2384800.
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J Nucl Med. 1990 Aug;31(8):1328-34.

Synthesis and preliminary evaluation of carbon-11-meta-hydroxyephedrine: a false transmitter agent for heart neuronal imaging.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

K C Rosenspire, M S Haka, M E Van Dort, D M Jewett, D L Gildersleeve, M Schwaiger, D M Wieland

Affiliations

  1. Division of Nuclear Medicine, University of Michigan Medical Center, Ann Arbor 48109-0552.

PMID: 2384800
Free Article

Abstract

Carbon-11-meta-hydroxyephedrine is a new radiotracer developed for mapping the sympathetic nerves of the heart. Carbon-11-meta-hydroxyephedrine is synthesized by direct N-methylation of metaraminol with [11C]methyl iodide in dimethyl formamide/dimethyl sulfoxide and purified by semi-preparative reversed-phase HPLC. Total synthesis time is 45 min from end-of-bombardment. Carbon-11-meta-hydroxyephedrine is produced in 40%-50% corrected radiochemical yield with a specific activity of 900 Ci/mmol. Routine radiochemical and chemical purity are 95% and 98%, respectively. Biodistribution studies in rats show high myocardial uptake. Pretreatment with desipramine, a drug known to selectively block neuronal uptake, results in a 92% decrease in tracer accumulation in the myocardium. Metabolic studies in guinea pigs show less than 5% metabolites in heart tissue 30 min after intravenous injection suggesting that [11C]meta-hydroxyephedrine is suitable for kinetic modeling. These preliminary results support this new tracer as a clinical agent for neuronal imaging of the heart.

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