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Ueda N, Muramatsu I, Fujiwara M. Prostaglandins enhance trigeminal substance P-ergic responses in the rabbit iris sphincter muscles. Brain Res. 1985;337(2):347-51doi: 10.1016/0006-8993(85)90073-3.
Ueda, N., Muramatsu, I., & Fujiwara, M. (1985). Prostaglandins enhance trigeminal substance P-ergic responses in the rabbit iris sphincter muscles. Brain research, 337(2), 347-51. https://doi.org/10.1016/0006-8993(85)90073-3
Ueda, N, et al. "Prostaglandins enhance trigeminal substance P-ergic responses in the rabbit iris sphincter muscles." Brain research vol. 337,2 (1985): 347-51. doi: https://doi.org/10.1016/0006-8993(85)90073-3
Ueda N, Muramatsu I, Fujiwara M. Prostaglandins enhance trigeminal substance P-ergic responses in the rabbit iris sphincter muscles. Brain Res. 1985 Jul 01;337(2):347-51. doi: 10.1016/0006-8993(85)90073-3. PMID: 2411336.
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Brain Res. 1985 Jul 01;337(2):347-51. doi: 10.1016/0006-8993(85)90073-3.

Prostaglandins enhance trigeminal substance P-ergic responses in the rabbit iris sphincter muscles.

Brain research

N Ueda, I Muramatsu, M Fujiwara

PMID: 2411336 DOI: 10.1016/0006-8993(85)90073-3

Abstract

Contractile responses due to substance P released from the trigeminal nerve were observed after electrical transmural stimulation or exogenous application of bradykinin in the isolated rabbit iris sphincter muscle. Prostaglandins, particulary prostaglandin E1, enhanced and indomethacin inhibited these substance P-ergic responses. Since the responses to exogenously applied substance P were neither affected by prostaglandins nor indomethacin, it was suggested that prostaglandins acted presynaptically to enhance the release of substance P from the trigeminal nerve terminals.

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