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Ichikawa H, Ebinuma H, Tada S, et al. A case of severe cholestatic jaundice with hyperthyroidism successfully treated with methimazole. Clin J Gastroenterol. 2009;2(4):315-319doi: 10.1007/s12328-009-0094-8.
Ichikawa, H., Ebinuma, H., Tada, S., Ojiro, K., Yamagishi, Y., Tsukada, N., Hongou, E., Funae, O., Irie, R., Saito, H., & Hibi, T. (2009). A case of severe cholestatic jaundice with hyperthyroidism successfully treated with methimazole. Clinical journal of gastroenterology, 2(4), 315-319. https://doi.org/10.1007/s12328-009-0094-8
Ichikawa, Hitoshi, et al. "A case of severe cholestatic jaundice with hyperthyroidism successfully treated with methimazole." Clinical journal of gastroenterology vol. 2,4 (2009): 315-319. doi: https://doi.org/10.1007/s12328-009-0094-8
Ichikawa H, Ebinuma H, Tada S, Ojiro K, Yamagishi Y, Tsukada N, Hongou E, Funae O, Irie R, Saito H, Hibi T. A case of severe cholestatic jaundice with hyperthyroidism successfully treated with methimazole. Clin J Gastroenterol. 2009 Aug;2(4):315-319. doi: 10.1007/s12328-009-0094-8. Epub 2009 Jun 17. PMID: 26192433.
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Clin J Gastroenterol. 2009 Aug;2(4):315-319. doi: 10.1007/s12328-009-0094-8. Epub 2009 Jun 17.

A case of severe cholestatic jaundice with hyperthyroidism successfully treated with methimazole.

Clinical journal of gastroenterology

Hitoshi Ichikawa, Hirotoshi Ebinuma, Shinichirou Tada, Keisuke Ojiro, Yoshiyuki Yamagishi, Nobuhiro Tsukada, Emi Hongou, Osamu Funae, Rie Irie, Hidetsugu Saito, Toshifumi Hibi

Affiliations

  1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
  2. Department of Internal Medicine, Saiseikai Central Hospital, Tokyo, Japan.
  3. Division of Diagnostic Pathology, School of Medicine, Keio University, Tokyo, Japan.
  4. Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. [email protected].

PMID: 26192433 DOI: 10.1007/s12328-009-0094-8

Abstract

Liver dysfunction is a common complication observed in patients with hyperthyroidism, however the dysfunction is always mild and obvious jaundice is rarely observed. We present the case of a 43-year-old man who suffered from hyperthyroidism complicated by severe jaundice. The jaundice likely occurred as a secondary consequence of cholestasis due to hyperthyroidism, since other causes such as drug-induced or autoimmune liver dysfunction were ruled out. Treatment with methimazole improved severe cholestatic jaundice in parallel with normalization of thyroid function. The mechanism of cholestasis as a secondary complication of hyperthyroidism has not been uncovered and there is no specific biochemical marker for cholestasis due to this hormonal disease at present. This case serves as a reminder that severe jaundice can be a manifestation of simple hyperthyroidism, and that administration of antithyroid drugs is an effective treatment for severe cholestatic jaundice in such cases.

Keywords: Cholestatis; Hyperthyroidism; Jaundice

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