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Kitazawa T, Kudo K, Ishigami M, et al. Evidence that a substance P-like peptide mediates the non-cholinergic excitatory response of the carp intestinal bulb (Cyprinus carpio). Naunyn Schmiedebergs Arch Pharmacol. 1988;338(1):68-73doi: 10.1007/BF00168814.
Kitazawa, T., Kudo, K., Ishigami, M., Furuhashi, H., Temma, K., & Kondo, H. (1988). Evidence that a substance P-like peptide mediates the non-cholinergic excitatory response of the carp intestinal bulb (Cyprinus carpio). Naunyn-Schmiedeberg's archives of pharmacology, 338(1), 68-73. https://doi.org/10.1007/BF00168814
Kitazawa, T, et al. "Evidence that a substance P-like peptide mediates the non-cholinergic excitatory response of the carp intestinal bulb (Cyprinus carpio)." Naunyn-Schmiedeberg's archives of pharmacology vol. 338,1 (1988): 68-73. doi: https://doi.org/10.1007/BF00168814
Kitazawa T, Kudo K, Ishigami M, Furuhashi H, Temma K, Kondo H. Evidence that a substance P-like peptide mediates the non-cholinergic excitatory response of the carp intestinal bulb (Cyprinus carpio). Naunyn Schmiedebergs Arch Pharmacol. 1988 Jul;338(1):68-73. doi: 10.1007/BF00168814. PMID: 2467211.
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Naunyn Schmiedebergs Arch Pharmacol. 1988 Jul;338(1):68-73. doi: 10.1007/BF00168814.

Evidence that a substance P-like peptide mediates the non-cholinergic excitatory response of the carp intestinal bulb (Cyprinus carpio).

Naunyn-Schmiedeberg's archives of pharmacology

T Kitazawa, K Kudo, M Ishigami, H Furuhashi, K Temma, H Kondo

Affiliations

  1. Department of Veterinary Pharmacology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Aomori, Japan.

PMID: 2467211 DOI: 10.1007/BF00168814

Abstract

The participation of substance P in the noncholinergic contraction induced by transmural stimulation (TMS) of the carp intestinal bulb was examined. In the presence of atropine, substance P caused the contraction of carp intestinal bulb smooth muscle in a concentration dependent manner (1 nmol/l - 1 mumol/l). The EC50 value was 28 +/- 7 nmol/l (n = 6). Substance P-induced desensitization (1 mumol/l for 15 min), decreased the response to substance P and the atropine-resistant contraction induced by TMS (20 Hz) selectively. In contrast, in the absence of atropine, the contraction induced by TMS (20 Hz) was slightly attenuated with the substance P-induced desensitization. The acid extract obtained from the carp intestinal bulb contained a smooth muscle excitatory material whose pharmacological properties were consistent with those of substance P. The present results indicate that a substance P-like peptide is present in the carp intestinal bulb which is involved in the non-cholinergic contraction induced by TMS.

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