Rinsho Ketsueki. 1989 Jul;30(7):1067-73.

[Sézary syndrome associated with hepatocellular carcinoma and monoclonal gammopathy--a case report].

[Rinsho ketsueki] The Japanese journal of clinical hematology

[Article in Japanese]
R Shimamura, T Kaneko, E Morioka, T Shibuya, H Ishibashi, Y Niho

PMID: 2554013

Abstract

We treated 54-year-old Japanese man with a large cell type of Sézary syndrome. He had generalized erythrodermia, superficial lymphadenopathy, atypical lymphocytes in the peripheral blood, anti-HTLV-I antibody negativity and chromosomal abnormality. The patient was a hepatitis B virus carrier, and was complicated with hepatocellular carcinoma and monoclonal gammopathy of IgG, lambda type. Sézary syndrome is a T cell malignancy, the clinical course of which is relatively mild and chronic; accordingly, this case showed no crisis under chemotherapy. However, the patient died due to rapid growth of the hepatoma. Although case reports of Sézary syndrome complicated with other malignancies are very few, the occurrence of malignancies is possible because of decreased immunological function in the patients. In this case, hepatitis B virus might participate in the hepatic oncogenesis under dysfunction of helper/inducer cells. In addition, the complication of monoclonal gammopathy was also interesting from the standpoint of the helper function of Sézary cells.

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Substances

• Immunoglobulin G
• Immunoglobulin lambda-Chains

MeSH terms

• Carcinoma, Hepatocellular / complications
• Humans
• Immunoglobulin G / metabolism
• Immunoglobulin lambda-Chains / metabolism
• Liver Neoplasms / complications
• Male
• Middle Aged
• Paraproteinemias / complications
• Paraproteinemias / immunology
• Sezary Syndrome / complications
• Sezary Syndrome / immunology

Publication Types

• Case Reports
• English Abstract
• Journal Article

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