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Singh N, Kumar R, Malhotra A, et al. Diagnostic utility of fluorodeoxyglucose positron emission tomography/computed tomography in pyrexia of unknown origin. Indian J Nucl Med. 2015;30(3):204-12doi: 10.4103/0972-3919.158528.
Singh, N., Kumar, R., Malhotra, A., Bhalla, A. S., Kumar, U., & Sood, R. (2015). Diagnostic utility of fluorodeoxyglucose positron emission tomography/computed tomography in pyrexia of unknown origin. Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India, 30(3), 204-12. https://doi.org/10.4103/0972-3919.158528
Singh, Nidhi, et al. "Diagnostic utility of fluorodeoxyglucose positron emission tomography/computed tomography in pyrexia of unknown origin." Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India vol. 30,3 (2015): 204-12. doi: https://doi.org/10.4103/0972-3919.158528
Singh N, Kumar R, Malhotra A, Bhalla AS, Kumar U, Sood R. Diagnostic utility of fluorodeoxyglucose positron emission tomography/computed tomography in pyrexia of unknown origin. Indian J Nucl Med. 2015 Jul-Sep;30(3):204-12. doi: 10.4103/0972-3919.158528. PMID: 26170562; PMCID: PMC4479908.
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Indian J Nucl Med. 2015 Jul-Sep;30(3):204-12. doi: 10.4103/0972-3919.158528.

Diagnostic utility of fluorodeoxyglucose positron emission tomography/computed tomography in pyrexia of unknown origin.

Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India

Nidhi Singh, Rakesh Kumar, Arun Malhotra, Ashu Seith Bhalla, Uma Kumar, Rita Sood

Affiliations

  1. Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
  2. Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
  3. Department of Nuclear Medicine, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
  4. Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India.

PMID: 26170562 PMCID: PMC4479908 DOI: 10.4103/0972-3919.158528

Abstract

PURPOSE OF THE STUDY: The present study was undertaken to evaluate the diagnostic utility of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) in patients presenting as pyrexia of unknown origin (PUO).

MATERIALS AND METHODS: Forty-seven patients (31 males and 16 females; mean age of 42.7 ± 19.96 years) presenting as PUO to the Department of Medicine at the All India Institute of Medical Sciences, New Delhi over a period of 2 years underwent F-18 FDG PET/CT. PET ⁄ CT was considered supportive when its results correlated with the final definitive diagnosis. Final diagnosis was made on the basis of combined evaluation of history, clinical findings, investigations, and response to treatment.

RESULTS: Thirty-five PET/CT studies (74.5%) were positive. However, only 18 (38.3%) were supportive of the final diagnosis. In three patients (6.4%), PET/CT was considered diagnostic as none of the other investigations including contrast-enhanced computed tomography of chest and abdomen, and directed tissue sampling could lead to the final diagnosis. All these three patients were diagnosed as aortoarteritis.

CONCLUSION: Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography is an important emerging modality in the workup of PUO. It supported the final diagnosis in 38% of our patients and was diagnostic in 6.4% of patients. Thus, PET/CT should only be considered as second-line investigation for the diagnostic evaluation of PUO; especially in suspected noninfectious inflammatory disorders.

Keywords: Fever; fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography; pyrexia; pyrexia of unknown origin

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