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Loeffler M, Engel C, Ahnert P, et al. The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany. BMC Public Health. 2015;15:691doi: 10.1186/s12889-015-1983-z.
Loeffler, M., Engel, C., Ahnert, P., Alfermann, D., Arelin, K., Baber, R., Beutner, F., Binder, H., Brähler, E., Burkhardt, R., Ceglarek, U., Enzenbach, C., Fuchs, M., Glaesmer, H., Girlich, F., Hagendorff, A., Häntzsch, M., Hegerl, U., Henger, S., Hensch, T., Hinz, A., Holzendorf, V., Husser, D., Kersting, A., Kiel, A., Kirsten, T., Kratzsch, J., Krohn, K., Luck, T., Melzer, S., Netto, J., Nüchter, M., Raschpichler, M., Rauscher, F. G., Riedel-Heller, S. G., Sander, C., Scholz, M., Schönknecht, P., Schroeter, M. L., Simon, J. C., Speer, R., Stäker, J., Stein, R., Stöbel-Richter, Y., Stumvoll, M., Tarnok, A., Teren, A., Teupser, D., Then, F. S., Tönjes, A., Treudler, R., Villringer, A., Weissgerber, A., Wiedemann, P., Zachariae, S., Wirkner, K., & Thiery, J. (2015). The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany. BMC public health, 15691. https://doi.org/10.1186/s12889-015-1983-z
Loeffler, Markus, et al. "The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany." BMC public health vol. 15 (2015): 691. doi: https://doi.org/10.1186/s12889-015-1983-z
Loeffler M, Engel C, Ahnert P, Alfermann D, Arelin K, Baber R, Beutner F, Binder H, Brähler E, Burkhardt R, Ceglarek U, Enzenbach C, Fuchs M, Glaesmer H, Girlich F, Hagendorff A, Häntzsch M, Hegerl U, Henger S, Hensch T, Hinz A, Holzendorf V, Husser D, Kersting A, Kiel A, Kirsten T, Kratzsch J, Krohn K, Luck T, Melzer S, Netto J, Nüchter M, Raschpichler M, Rauscher FG, Riedel-Heller SG, Sander C, Scholz M, Schönknecht P, Schroeter ML, Simon JC, Speer R, Stäker J, Stein R, Stöbel-Richter Y, Stumvoll M, Tarnok A, Teren A, Teupser D, Then FS, Tönjes A, Treudler R, Villringer A, Weissgerber A, Wiedemann P, Zachariae S, Wirkner K, Thiery J. The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany. BMC Public Health. 2015 Jul 22;15:691. doi: 10.1186/s12889-015-1983-z. PMID: 26197779; PMCID: PMC4509697.
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BMC Public Health. 2015 Jul 22;15:691. doi: 10.1186/s12889-015-1983-z.

The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany.

BMC public health

Markus Loeffler, Christoph Engel, Peter Ahnert, Dorothee Alfermann, Katrin Arelin, Ronny Baber, Frank Beutner, Hans Binder, Elmar Brähler, Ralph Burkhardt, Uta Ceglarek, Cornelia Enzenbach, Michael Fuchs, Heide Glaesmer, Friederike Girlich, Andreas Hagendorff, Madlen Häntzsch, Ulrich Hegerl, Sylvia Henger, Tilman Hensch, Andreas Hinz, Volker Holzendorf, Daniela Husser, Anette Kersting, Alexander Kiel, Toralf Kirsten, Jürgen Kratzsch, Knut Krohn, Tobias Luck, Susanne Melzer, Jeffrey Netto, Matthias Nüchter, Matthias Raschpichler, Franziska G Rauscher, Steffi G Riedel-Heller, Christian Sander, Markus Scholz, Peter Schönknecht, Matthias L Schroeter, Jan-Christoph Simon, Ronald Speer, Julia Stäker, Robert Stein, Yve Stöbel-Richter, Michael Stumvoll, Attila Tarnok, Andrej Teren, Daniel Teupser, Francisca S Then, Anke Tönjes, Regina Treudler, Arno Villringer, Alexander Weissgerber, Peter Wiedemann, Silke Zachariae, Kerstin Wirkner, Joachim Thiery

Affiliations

  1. LIFE - Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. [email protected].
  2. Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany. [email protected].
  3. LIFE - Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
  4. Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany.
  5. Department of Sport and Exercise Psychology, University of Leipzig, Leipzig, Germany.
  6. Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
  7. Clinic of Cognitive Neurology, University of Leipzig, Leipzig, Germany.
  8. Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany.
  9. Department of Internal Medicine/Cardiology, Leipzig Heart Centre, Leipzig, Germany.
  10. Interdisciplinary Centre for Bioinformatics, University of Leipzig, Leipzig, Germany.
  11. Department of Psychosomatic Medicine and Psychotherapy, Universal Medical Centre Mainz, Mainz, Germany.
  12. Department of Otorhinolaryngology, Section of Phoniatrics and Audiology, University of Leipzig, Leipzig, Germany.
  13. Department of Medical Psychology and Medical Sociology, University of Leipzig, Leipzig, Germany.
  14. Department of Cardiology-Angiology, University of Leipzig, Leipzig, Germany.
  15. Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany.
  16. Clinical Trial Centre Leipzig - Coordinating Centre for Clinical Trials, University of Leipzig, Leipzig, Germany.
  17. Department of Electrophysiology, Leipzig Heart Centre, Leipzig, Germany.
  18. Clinic of Psychosomatic Medicine and Psychotherapy, University of Leipzig, Leipzig, Germany.
  19. Interdisciplinary Centre for Clinical Research (IZKF), University of Leipzig, Leipzig, Germany.
  20. Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany.
  21. Department of Pediatric Cardiology, Leipzig Heart Centre, Leipzig, Germany.
  22. Department of Radiology, University of Leipzig, Leipzig, Germany.
  23. Department of Ophthalmology, University of Leipzig, Leipzig, Germany.
  24. Department of Dermatology, Venereology and Allergology, University of Leipzig, Leipzig, Germany.
  25. Medical Department, Division of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.

PMID: 26197779 PMCID: PMC4509697 DOI: 10.1186/s12889-015-1983-z

Abstract

BACKGROUND: The LIFE-Adult-Study is a population-based cohort study, which has recently completed the baseline examination of 10,000 randomly selected participants from Leipzig, a major city with 550,000 inhabitants in the east of Germany. It is the first study of this kind and size in an urban population in the eastern part of Germany. The study is conducted by the Leipzig Research Centre for Civilization Diseases (LIFE). Our objective is to investigate prevalences, early onset markers, genetic predispositions, and the role of lifestyle factors of major civilization diseases, with primary focus on metabolic and vascular diseases, heart function, cognitive impairment, brain function, depression, sleep disorders and vigilance dysregulation, retinal and optic nerve degeneration, and allergies.

METHODS/DESIGN: The study covers a main age range from 40-79 years with particular deep phenotyping in elderly participants above the age of 60. The baseline examination was conducted from August 2011 to November 2014. All participants underwent an extensive core assessment programme (5-6 h) including structured interviews, questionnaires, physical examinations, and biospecimen collection. Participants over 60 underwent two additional assessment programmes (3-4 h each) on two separate visits including deeper cognitive testing, brain magnetic resonance imaging, diagnostic interviews for depression, and electroencephalography.

DISCUSSION: The participation rate was 33 %. The assessment programme was accepted well and completely passed by almost all participants. Biomarker analyses have already been performed in all participants. Genotype, transcriptome and metabolome analyses have been conducted in subgroups. The first follow-up examination will commence in 2016.

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