Display options
Cite
Ramadori P, Weiskirchen R, Trebicka J, et al. Mouse models of metabolic liver injury. Lab Anim. 2015;49(1):47-58doi: 10.1177/0023677215570078.
Ramadori, P., Weiskirchen, R., Trebicka, J., & Streetz, K. (2015). Mouse models of metabolic liver injury. Laboratory animals, 49(1), 47-58. https://doi.org/10.1177/0023677215570078
Ramadori, P, et al. "Mouse models of metabolic liver injury." Laboratory animals vol. 49,1 (2015): 47-58. doi: https://doi.org/10.1177/0023677215570078
Ramadori P, Weiskirchen R, Trebicka J, Streetz K. Mouse models of metabolic liver injury. Lab Anim. 2015 Apr;49(1):47-58. doi: 10.1177/0023677215570078. PMID: 25835738.
Copy Download .nbib Format: NLM
Share it on

Lab Anim. 2015 Apr;49(1):47-58. doi: 10.1177/0023677215570078.

Mouse models of metabolic liver injury.

Laboratory animals

P Ramadori, R Weiskirchen, J Trebicka, K Streetz

Affiliations

  1. Department of Internal Medicine III, RWTH University Hospital Aachen, Aachen, Germany.
  2. Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH Aachen University, Aachen, Germany.
  3. Department of Internal Medicine I, University of Bonn, Bonn, Germany [email protected] [email protected].

PMID: 25835738 DOI: 10.1177/0023677215570078

Abstract

Metabolic liver injury is one of the fastest growing health problems worldwide. Alcoholic and non-alcoholic fatty livers have been shown to be associated with progression to end-stage liver diseases, as well as to liver cancers, in humans. More importantly, there are no validated therapies for these disorders, therefore intensive research is required in this area. This review of standard operation procedures focuses on the experimental models of fatty liver disease in the mouse. Firstly, use of these experimental models might improve understanding of underlying mechanisms, and secondly this might help to test potential therapeutic options. This article includes, besides a short historic background, an insight into the pathobiochemical mechanisms and detailed experimental procedures as well as the practical implementation of these models.

© The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Keywords: Lieber-DeCarli; MCD; NAFLD; NASH; fat; inflammation; steatosis

MeSH terms

Publication Types