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Biull Eksp Biol Med. 1987 Feb;103(2):221-3.

[Action of dextran-modified hyaluronidase in experimental silicosis].

Biulleten' eksperimental'noi biologii i meditsiny

[Article in Russian]
O G Arkhipova, V V Iaglov, A V Maksimenko, L V Pavlovskaia, O Iu Konovalova

PMID: 2434158

Abstract

Dextran-modified hyaluronidase was inhaled or intraperitoneally injected for 4 months to mice with silicosis. Stabilized hyaluronidase was shown to have a marked inhibitory effect on the development of lung fibrosis. Drug inhalation proved to be the most effective. An antifibrotic effect of dextran itself has been observed.

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