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Stone JA, Wilkes PR, Keane PM, et al. Pericardial pressure attenuates release of atriopeptin in volume-expanded dogs. Am J Physiol. 1989;256(3):H648-54doi: 10.1152/ajpheart.1989.256.3.H648.
Stone, J. A., Wilkes, P. R., Keane, P. M., Smith, E. R., & Tyberg, J. V. (1989). Pericardial pressure attenuates release of atriopeptin in volume-expanded dogs. The American journal of physiology, 256(3), H648-54. https://doi.org/10.1152/ajpheart.1989.256.3.H648
Stone, J A, et al. "Pericardial pressure attenuates release of atriopeptin in volume-expanded dogs." The American journal of physiology vol. 256,3 (1989): H648-54. doi: https://doi.org/10.1152/ajpheart.1989.256.3.H648
Stone JA, Wilkes PR, Keane PM, Smith ER, Tyberg JV. Pericardial pressure attenuates release of atriopeptin in volume-expanded dogs. Am J Physiol. 1989 Mar;256(3):H648-54. doi: 10.1152/ajpheart.1989.256.3.H648. PMID: 2522279.
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Am J Physiol. 1989 Mar;256(3):H648-54. doi: 10.1152/ajpheart.1989.256.3.H648.

Pericardial pressure attenuates release of atriopeptin in volume-expanded dogs.

The American journal of physiology

J A Stone, P R Wilkes, P M Keane, E R Smith, J V Tyberg

Affiliations

  1. Department of Medicine, University of Calgary, Faculty of Medicine, Alberta, Canada.

PMID: 2522279 DOI: 10.1152/ajpheart.1989.256.3.H648

Abstract

The role of the pericardium in the release of atriopeptin (AP) was examined, utilizing two separate protocols, in alpha-chloralose-anesthetized dogs. Protocol I consisted of an experimental group (9 dogs), in which the pericardium was incised to allow instrumentation and reapproximated, and a control group (6 dogs), in which the pericardium was left undisturbed. In the experimental group, mean right atrial pressure (Pra) was elevated from a control value of 1.8 +/- 0.9 mmHg (mean +/- SD) to 8.3 +/- 0.8 mmHg for 40 min by volume expansion with isoncotic, lactated Ringer solution. After this period of volume expansion, the pericardium was removed while holding Pra at 8 mmHg. During volume expansion, arterial blood samples for AP analysis were taken at 5, 10, 15, 20, 30, and 40 min, pre- and postpericardiectomy. A similar protocol was followed in the control group. At a Pra of 8 mmHg prepericardiectomy, the plasma AP concentration was 76 +/- 17 pM/l and 74 +/- 38 pM/l in the experimental and control groups, respectively. However, after pericardiectomy, AP levels increased significantly in both the experimental group (136 +/- 41 pM/l; P less than 0.001) and the control group (107 +/- 53 pM/l; P less than 0.025). In protocol II (6 dogs), the pericardium was removed before volume expansion, and Pra was elevated by 2- to 3-mmHg increments and maintained for periods of 13 min at each pressure. AP concentration did not increase until Pra reached 3-4 mmHg.(ABSTRACT TRUNCATED AT 250 WORDS)

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