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Dunaway GA, Kasten TP. Physiological relevance of the changing subunit composition and regulatory properties of the 6-phosphofructo-1-kinase isozyme pools during heart and muscle development. Mol Cell Biochem. 1989;87(1):71-7doi: 10.1007/BF00421084.
Dunaway, G. A., & Kasten, T. P. (1989). Physiological relevance of the changing subunit composition and regulatory properties of the 6-phosphofructo-1-kinase isozyme pools during heart and muscle development. Molecular and cellular biochemistry, 87(1), 71-7. https://doi.org/10.1007/BF00421084
Dunaway, G A, and Kasten, T P. "Physiological relevance of the changing subunit composition and regulatory properties of the 6-phosphofructo-1-kinase isozyme pools during heart and muscle development." Molecular and cellular biochemistry vol. 87,1 (1989): 71-7. doi: https://doi.org/10.1007/BF00421084
Dunaway GA, Kasten TP. Physiological relevance of the changing subunit composition and regulatory properties of the 6-phosphofructo-1-kinase isozyme pools during heart and muscle development. Mol Cell Biochem. 1989 May 04;87(1):71-7. doi: 10.1007/BF00421084. PMID: 2549392.
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Mol Cell Biochem. 1989 May 04;87(1):71-7. doi: 10.1007/BF00421084.

Physiological relevance of the changing subunit composition and regulatory properties of the 6-phosphofructo-1-kinase isozyme pools during heart and muscle development.

Molecular and cellular biochemistry

G A Dunaway, T P Kasten

Affiliations

  1. Department of Pharmacology, Southern Illinois University School of Medicine, Springfield 62794-9230.

PMID: 2549392 DOI: 10.1007/BF00421084

Abstract

During postnatal development, the subunit compositions of the 6-phosphofructo-1-kinase isozyme pools of heart and skeletal muscle are known to change. The isozyme pools from fetal muscle were composed of the L-type (60%), and M-type (36%) and C-type (4%) subunits and the isozymes from fetal and early neonatal heart contain nearly equal amounts of all three subunits. During postnatal development of both tissues, the proportion of the M-type subunit increases until it is the only type present in adult muscle and the major subunit in adult heart (75%). The isozyme pool from fetal muscle exhibit a decreased affinity for fructose-6-P and a greater susceptibility to ATP inhibition compared to the M-rich isozymes which are subsequently present. The isozyme pools from fetal and early neonatal heart, if compared to the M-rich isozymes which are present later during heart development and to the fetal muscle isozymes, exhibited the least affinity for fructose-6-P and the greatest susceptibility to ATP inhibition. Comparison of the isozyme pools containing little or no C-type subunit with those from fetal and early neonatal heart clearly indicates that the presence of substantial levels of the C-type subunit imposed a decreased ability for fructose-2,6-P2 to both lower affinity for fructose-6-P and antagonize sensitivity to ATP inhibition. Although still not thoroughly appreciated, it appears that the changing nature of the isozyme pools in these tissues permits regulation of glucose metabolism in a manner which allows efficient utilization of nutritional opportunities and which adequately meets the energy requirements of each tissue at different stages of development.

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