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Rolih SD. High-titer, low-avidity (HTLA) antibodies and antigens: a review. Transfus Med Rev. 1989;3(2):128-39doi: 10.1016/s0887-7963(89)70074-2.
Rolih, S. D. (1989). High-titer, low-avidity (HTLA) antibodies and antigens: a review. Transfusion medicine reviews, 3(2), 128-39. https://doi.org/10.1016/s0887-7963(89)70074-2
Rolih, S D. "High-titer, low-avidity (HTLA) antibodies and antigens: a review." Transfusion medicine reviews vol. 3,2 (1989): 128-39. doi: https://doi.org/10.1016/s0887-7963(89)70074-2
Rolih SD. High-titer, low-avidity (HTLA) antibodies and antigens: a review. Transfus Med Rev. 1989 Apr;3(2):128-39. doi: 10.1016/s0887-7963(89)70074-2. PMID: 2520549.
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Transfus Med Rev. 1989 Apr;3(2):128-39. doi: 10.1016/s0887-7963(89)70074-2.

High-titer, low-avidity (HTLA) antibodies and antigens: a review.

Transfusion medicine reviews

S D Rolih

Affiliations

  1. Immucor, Inc. Norcross, GA 30091-5625.

PMID: 2520549 DOI: 10.1016/s0887-7963(89)70074-2

Abstract

Antibodies that react to HTLA characteristics cause difficulties in serologic testing because of the weak reactions they produce in the indirect antiglobulin test. Those specificities that are more frequently encountered (anti-Yka, -McCa, -Kna, -Ch) are directed toward antigens of high incidence in both the white and black populations. They have not been shown to cause significant destruction of transfused antigen-positive red cells. The antibodies create problems in serologic tests because the reactions they produce interfere with the identification of reactions due to other, clinically significant antibodies.

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