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Köhler JR, Casadevall A, Perfect J. The spectrum of fungi that infects humans. Cold Spring Harb Perspect Med. 2014;5(1):a019273doi: 10.1101/cshperspect.a019273.
Köhler, J. R., Casadevall, A., & Perfect, J. (2014). The spectrum of fungi that infects humans. Cold Spring Harbor perspectives in medicine, 5(1), a019273. https://doi.org/10.1101/cshperspect.a019273
Köhler, Julia R, et al. "The spectrum of fungi that infects humans." Cold Spring Harbor perspectives in medicine vol. 5,1 (2014): a019273. doi: https://doi.org/10.1101/cshperspect.a019273
Köhler JR, Casadevall A, Perfect J. The spectrum of fungi that infects humans. Cold Spring Harb Perspect Med. 2014 Nov 03;5(1):a019273. doi: 10.1101/cshperspect.a019273. PMID: 25367975; PMCID: PMC4292074.
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Cold Spring Harb Perspect Med. 2014 Nov 03;5(1):a019273. doi: 10.1101/cshperspect.a019273.

The spectrum of fungi that infects humans.

Cold Spring Harbor perspectives in medicine

Julia R Köhler, Arturo Casadevall, John Perfect

Affiliations

  1. Division of Infectious Diseases, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
  2. Departments of Microbiology and Immunology and Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, New York, New York 10461.
  3. Division of Infectious Diseases, Duke Medical Center, Durham, North Carolina 27710.

PMID: 25367975 PMCID: PMC4292074 DOI: 10.1101/cshperspect.a019273

Abstract

Few among the millions of fungal species fulfill four basic conditions necessary to infect humans: high temperature tolerance, ability to invade the human host, lysis and absorption of human tissue, and resistance to the human immune system. In previously healthy individuals, invasive fungal disease is rare because animals' sophisticated immune systems evolved in constant response to fungal challenges. In contrast, fungal diseases occur frequently in immunocompromised patients. Paradoxically, successes of modern medicine have put increasing numbers of patients at risk for invasive fungal infections. Uncontrolled HIV infection additionally makes millions vulnerable to lethal fungal diseases. A concerted scientific and social effort is needed to meet these challenges.

Copyright © 2015 Cold Spring Harbor Laboratory Press; all rights reserved.

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