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De Giovanni C, Nanni P, Nicoletti G, et al. Metastatic ability and differentiative properties of a new cell line of human embryonal rhabdomyosarcoma (CCA). Anticancer Res. 1989;9(6):1943-9
De Giovanni, C., Nanni, P., Nicoletti, G., Ceccarelli, C., Scotlandi, K., Landuzzi, L., & Lollini, P. L. (1989). Metastatic ability and differentiative properties of a new cell line of human embryonal rhabdomyosarcoma (CCA). Anticancer research, 9(6), 1943-9.
De Giovanni, C, et al. "Metastatic ability and differentiative properties of a new cell line of human embryonal rhabdomyosarcoma (CCA)." Anticancer research vol. 9,6 (1989): 1943-9.
De Giovanni C, Nanni P, Nicoletti G, Ceccarelli C, Scotlandi K, Landuzzi L, Lollini PL. Metastatic ability and differentiative properties of a new cell line of human embryonal rhabdomyosarcoma (CCA). Anticancer Res. 1989 Nov-Dec;9(6):1943-9. PMID: 2516717.
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Anticancer Res. 1989 Nov-Dec;9(6):1943-9.

Metastatic ability and differentiative properties of a new cell line of human embryonal rhabdomyosarcoma (CCA).

Anticancer research

C De Giovanni, P Nanni, G Nicoletti, C Ceccarelli, K Scotlandi, L Landuzzi, P L Lollini

Affiliations

  1. Centro Interdipartimentale di Ricerche sul Cancro G. Prodl., Università di Bologna, Italy.

PMID: 2516717

Abstract

A new cell line (CCA) was established from a human embryonal rhabdomyosarcoma. It showed an "early" myogenic differentiation pattern: vimentin expression was found in 100% of cells, desmin in about 40% and myosin of the embryonic isoform in about 5%. Class I HLA expression on CCA cells was undeterctable but was greatly increased by in vitro treatment with human recombinant interferon-gamma and only marginally increased by human recombinant tumour necrosis factor-alfa. CCA cell line was tumorigenic in nude mice after either subcutaneous or intramuscular injection; macroscopic spontaneous metastases were not detected. The ability to induce metastatic nodules in the lungs was found when CCA cells were injected intravenously in cyclophosphamide-pretreated nude mice and, at low frequency, in untreated nude mice.

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