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Karousou E, D'Angelo ML, Kouvidi K, et al. Collagen VI and hyaluronan: the common role in breast cancer. Biomed Res Int. 2014;2014:606458doi: 10.1155/2014/606458.
Karousou, E., D'Angelo, M. L., Kouvidi, K., Vigetti, D., Viola, M., Nikitovic, D., De Luca, G., & Passi, A. (2014). Collagen VI and hyaluronan: the common role in breast cancer. BioMed research international, 2014606458. https://doi.org/10.1155/2014/606458
Karousou, Evgenia, et al. "Collagen VI and hyaluronan: the common role in breast cancer." BioMed research international vol. 2014 (2014): 606458. doi: https://doi.org/10.1155/2014/606458
Karousou E, D'Angelo ML, Kouvidi K, Vigetti D, Viola M, Nikitovic D, De Luca G, Passi A. Collagen VI and hyaluronan: the common role in breast cancer. Biomed Res Int. 2014;2014:606458. doi: 10.1155/2014/606458. Epub 2014 Jul 14. PMID: 25126569; PMCID: PMC4121998.
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Biomed Res Int. 2014;2014:606458. doi: 10.1155/2014/606458. Epub 2014 Jul 14.

Collagen VI and hyaluronan: the common role in breast cancer.

BioMed research international

Evgenia Karousou, Maria Luisa D'Angelo, Katerina Kouvidi, Davide Vigetti, Manuela Viola, Dragana Nikitovic, Giancarlo De Luca, Alberto Passi

Affiliations

  1. Department of Surgery and Morphological Sciences, University of Insubria, Via J. H. Dunant 5, 21100 Varese, Italy.
  2. Department of Histology-Embryology, University of Crete, 71003 Heraklion, Greece.

PMID: 25126569 PMCID: PMC4121998 DOI: 10.1155/2014/606458

Abstract

Collagen VI and hyaluronan are widely distributed extracellular matrix macromolecules that play a crucial role in tissue development and are highly expressed in cancers. Both hyaluronan and collagen VI are upregulated in breast cancer, generating a microenvironment that promotes tumour progression and metastasis. A growing number of studies show that these two molecules are involved in inflammation and angiogenesis by recruiting macrophages and endothelial cells, respectively. Additionally, collagen VI induces epithelial-mesenchymal transition that is correlated to increased synthesis of hyaluronan in mammary cells. Hyaluronan has also a specific role in cellular functions that depends mainly on the size of the polymer, whereas the effect of collagen VI in tumour progression may be the result of the intact molecule or the C5 peptide of α3(VI) chain, known as endotrophin. Collectively, these findings strongly support the parallel role of these molecules in tumour progression and suggest that they may be used as prognostic factors for the breast cancer treatment.

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