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Röpcke G, Moen CJ, Hart AA, et al. Effects of the MHC on hormonal induction of mammary tumors and function of hypophyseal isografts in the mouse. Immunogenetics. 1990;31(5):347-55doi: 10.1007/BF02115009.
Röpcke, G., Moen, C. J., Hart, A. A., & Demant, P. (1990). Effects of the MHC on hormonal induction of mammary tumors and function of hypophyseal isografts in the mouse. Immunogenetics, 31(5), 347-55. https://doi.org/10.1007/BF02115009
Röpcke, G, et al. "Effects of the MHC on hormonal induction of mammary tumors and function of hypophyseal isografts in the mouse." Immunogenetics vol. 31,5 (1990): 347-55. doi: https://doi.org/10.1007/BF02115009
Röpcke G, Moen CJ, Hart AA, Demant P. Effects of the MHC on hormonal induction of mammary tumors and function of hypophyseal isografts in the mouse. Immunogenetics. 1990;31(5):347-55. doi: 10.1007/BF02115009. PMID: 2370079.
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Immunogenetics. 1990;31(5):347-55. doi: 10.1007/BF02115009.

Effects of the MHC on hormonal induction of mammary tumors and function of hypophyseal isografts in the mouse.

Immunogenetics

G Röpcke, C J Moen, A A Hart, P Demant

Affiliations

  1. Department of Molecular Genetics, The Netherlands Cancer Institute, Antoni van Leeuwenhoekhuis, Amsterdam.

PMID: 2370079 DOI: 10.1007/BF02115009

Abstract

While the role of the H-2 complex in the resistance to virally induced tumors has been extensively studied, little is known about its influence on the development of epithelial tumors of non-viral etiology, although such tumors are most prevalent in humans. Therefore, we analyzed the role of the H-2 complex in susceptibility to mammary tumors induced by hormonal stimulation from heterotopic hypophyseal isografts in H-2 congenic strains from C57BL/10, BALB/c, and O20/A backgrounds. This method of induction allows an assessment of the effect of H-2 genes on the function of various organs involved in this process. We found that the tumor susceptibility genes map to two segments: I-E-S, and to the right of S. The mechanisms by which the H-2 complex affects the induction of mammary tumors in C57BL/10 congenic strains seem to include an influence on several factors involved in the hormonal stimulation, because the susceptible B10 congenic strains have higher plasma levels of prolactin and the H-2 complex also affects the growth of hypophyseal isografts. Their size correlates with tumor development in individual mice in the resistant C57BL/10 congenic strains. We reported previously H-2-dependent differences in levels of the estrogen receptor in hypophysis. For this study, we measured the levels of estrogen receptors in uteri to asses the tissue specificity of this effect of H-2. However, no influence of the H-2 complex on estrogen receptor levels was observed in uteri. Strains from BALB/c and O20 backgrounds developed mammary tumors much earlier than the B10 congenic strains, indicating a strong influence of non-H-2 genes.

References

  1. J Natl Cancer Inst. 1989 Apr 5;81(7):512-7 - PubMed
  2. Immunogenetics. 1987;26(3):169-73 - PubMed
  3. Jpn J Cancer Res. 1987 May;78(5):494-8 - PubMed
  4. Genetics. 1983 Feb;103(2):263-76 - PubMed
  5. Cancer Res. 1988 Dec 1;48(23):6634-41 - PubMed
  6. Proc Natl Acad Sci U S A. 1988 Nov;85(22):8543-7 - PubMed
  7. Transplantation. 1971 Apr;11(4):426-8 - PubMed
  8. Immunogenetics. 1986;24(6):416-22 - PubMed
  9. J Exp Med. 1978 Mar 1;147(3):768-75 - PubMed
  10. Immunol Rev. 1981;60:5-22 - PubMed
  11. Int J Cancer. 1979 Aug;24(2):165-7 - PubMed
  12. Adv Cancer Res. 1989;53:117-79 - PubMed
  13. J Natl Cancer Inst. 1980 Nov;65(5):977-86 - PubMed
  14. Cancer Res. 1985 Aug;45(8):3448-53 - PubMed
  15. Immunogenetics. 1985;22(2):183-8 - PubMed
  16. Cancer Chemother Rep. 1966 Mar;50(3):163-70 - PubMed
  17. Int J Cancer. 1983 Apr 15;31(4):447-54 - PubMed
  18. Experientia. 1979 Aug 15;35(8):1103-4 - PubMed
  19. Cancer Res. 1978 Sep;38(9):2859-60 - PubMed
  20. Lancet. 1964 Dec 5;2(7371):1207-9 - PubMed
  21. Int J Cancer. 1987 Sep 15;40(3):372-7 - PubMed
  22. J Natl Cancer Inst. 1968 Jun;40(6):1259-72 - PubMed
  23. Transplant Proc. 1983 Dec;15(4):2101-3 - PubMed

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