Display options
Cite
Pearce WJ. The fetal cerebral circulation: three decades of exploration by the LLU Center for Perinatal Biology. Adv Exp Med Biol. 2014;814:177-91doi: 10.1007/978-1-4939-1031-1_16.
Pearce, W. J. (2014). The fetal cerebral circulation: three decades of exploration by the LLU Center for Perinatal Biology. Advances in experimental medicine and biology, 814177-91. https://doi.org/10.1007/978-1-4939-1031-1_16
Pearce, William J. "The fetal cerebral circulation: three decades of exploration by the LLU Center for Perinatal Biology." Advances in experimental medicine and biology vol. 814 (2014): 177-91. doi: https://doi.org/10.1007/978-1-4939-1031-1_16
Pearce WJ. The fetal cerebral circulation: three decades of exploration by the LLU Center for Perinatal Biology. Adv Exp Med Biol. 2014;814:177-91. doi: 10.1007/978-1-4939-1031-1_16. PMID: 25015811; PMCID: PMC4449335.
Copy Download .nbib Format: NLM
Share it on

Adv Exp Med Biol. 2014;814:177-91. doi: 10.1007/978-1-4939-1031-1_16.

The fetal cerebral circulation: three decades of exploration by the LLU Center for Perinatal Biology.

Advances in experimental medicine and biology

William J Pearce

Affiliations

  1. Center for Perinatal Biology, Loma Linda University School of Medicine, 92350, Loma Linda, CA, USA, [email protected].

PMID: 25015811 PMCID: PMC4449335 DOI: 10.1007/978-1-4939-1031-1_16

Abstract

For more than three decades, research programs in the Center of Perinatal Biology have focused on the vascular biology of the fetal cerebral circulation. In the 1980s, research in the Center demonstrated that cerebral autoregulation operated over a narrower pressure range, and was more vulnerable to insults, in fetuses than in adults. Other studies were among the first to establish that compared to adult cerebral arteries, fetal cerebral arteries were more hydrated, contained smaller smooth muscle cells and less connective tissue, and had endothelium less capable of producing NO. Work in the 1990s revealed that pregnancy depressed reactivity to NO in extra-cerebral arteries, but elevated it in cerebral arteries through effects involving changes in cGMP metabolism. Comparative studies verified that fetal lamb cerebral arteries were an excellent model for cerebral arteries from human infants. Biochemical studies demonstrated that cGMP metabolism was dramatically upregulated, but that contraction was far more dependent on calcium influx, in fetal compared to adult cerebral arteries. Further studies established that chronic hypoxia accelerates functional maturation of fetal cerebral arteries, as indicated by increased contractile responses to adrenergic agonists and perivascular adrenergic nerves. In the 2000s, studies of signal transduction established age-dependent roles for PKG, PKC, PKA, ERK, ODC, IP3, myofilament calcium sensitivity, and many other mechanisms. These diverse studies clearly demonstrated that fetal cerebral arteries were functionally quite distinct compared to adult cerebral arteries. In the current decade, research in the Center has expanded to a more molecular focus on epigenetic mechanisms and their role in fetal vascular adaptation to chronic hypoxia, maternal drug abuse, and nutrient deprivation. Overall, the past three decades have transformed thinking about, and understanding of, the fetal cerebral circulation due in no small part to the sustained research efforts by faculty and staff in the Center for Perinatal Biology.

References

  1. J Physiol. 2003 Jun 1;549(Pt 2):625-33 - PubMed
  2. J Physiol. 2007 Jan 1;578(Pt 1):359-70 - PubMed
  3. Arch Neurol. 1984 Jul;41(7):766-71 - PubMed
  4. J Appl Physiol (1985). 2006 Jan;100(1):225-32 - PubMed
  5. Pediatr Res. 1998 Aug;44(2):154-60 - PubMed
  6. Nat Rev Neurol. 2012 Dec;8(12):711-6 - PubMed
  7. Adv Exp Med Biol. 2011;701:225-32 - PubMed
  8. Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H1019-28 - PubMed
  9. Am J Physiol. 1999 Oct;277(4):R931-7 - PubMed
  10. Brain Res. 1997 Jul 25;763(2):232-8 - PubMed
  11. Brain Res Dev Brain Res. 2002 Feb 28;133(2):81-91 - PubMed
  12. Stroke. 1998 May;29(5):1037-46; discussion 1047 - PubMed
  13. J Dev Physiol. 1990 Apr;13(4):199-203 - PubMed
  14. J Soc Gynecol Investig. 2004 Oct;11(7):449-56 - PubMed
  15. Am J Physiol. 1997 Feb;272(2 Pt 2):R669-74 - PubMed
  16. J Appl Physiol (1985). 2009 Jul;107(1):192-9 - PubMed
  17. Biol Neonate. 2003;83(2):123-35 - PubMed
  18. Am J Physiol Regul Integr Comp Physiol. 2002 Jun;282(6):R1654-62 - PubMed
  19. J Physiol. 2003 Sep 1;551(Pt 2):691-703 - PubMed
  20. Pediatr Res. 1996 Jan;39(1):25-31 - PubMed
  21. Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1034-44 - PubMed
  22. Arch Int Pharmacodyn Ther. 1974 Apr;208(2):235-42 - PubMed
  23. Reprod Sci. 2007 Jan;14(1):51-8 - PubMed
  24. Rev Physiol Biochem Pharmacol. 1993;122:1-67 - PubMed
  25. J Appl Physiol (1985). 2003 Feb;94(2):724-32 - PubMed
  26. Am J Physiol Cell Physiol. 2012 Nov 15;303(10):C1090-103 - PubMed
  27. Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H732-40 - PubMed
  28. Pediatr Res. 2006 Nov;60(5):524-9 - PubMed
  29. Curr Opin Pediatr. 2001 Dec;13(6):506-16 - PubMed
  30. Pediatr Res. 1995 Oct;38(4):493-500 - PubMed
  31. Arch Neurol. 1983 May;40(5):261-6 - PubMed
  32. J Appl Physiol (1985). 2005 Jul;99(1):120-7 - PubMed
  33. Am J Physiol Regul Integr Comp Physiol. 2010 Nov;299(5):R1377-86 - PubMed
  34. Am J Obstet Gynecol. 2003 Jul;189(1):233-8 - PubMed
  35. Am J Physiol Regul Integr Comp Physiol. 2005 Jan;288(1):R16-24 - PubMed
  36. Pediatr Res. 1981 Jan;15(1):44-6 - PubMed
  37. Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H2220-7 - PubMed
  38. Transl Stroke Res. 2011 Sep;2(3):243-7 - PubMed
  39. Pediatr Neurol. 1995 Apr;12(3):191-6 - PubMed
  40. Am J Obstet Gynecol. 2006 Aug;195(2):535-41 - PubMed
  41. Am J Physiol Regul Integr Comp Physiol. 2001 Feb;280(2):R410-7 - PubMed
  42. Curr Vasc Pharmacol. 2013 Sep;11(5):544-63 - PubMed
  43. Am J Physiol Regul Integr Comp Physiol. 2002 Jan;282(1):R131-8 - PubMed
  44. Semin Perinatol. 1991 Feb;15(1):49-57 - PubMed
  45. Proc West Pharmacol Soc. 1991;34:247-54 - PubMed
  46. Brain Res. 1971 Mar 19;27(1):33-42 - PubMed
  47. Pediatr Res. 1994 Jun;35(6):729-32 - PubMed
  48. Pediatr Res. 2006 Dec;60(6):711-6 - PubMed
  49. Science. 1971 May 21;172(3985):850-1 - PubMed
  50. Am J Physiol. 1998 Sep;275(3):R742-53 - PubMed
  51. Placenta. 1994 Jun;15(4):365-75 - PubMed
  52. Reprod Sci. 2010 Mar;17(3):227-38 - PubMed
  53. Pediatr Res. 1995 Nov;38(5):652-6 - PubMed
  54. Pediatr Res. 1999 Oct;46(4):390-400 - PubMed
  55. Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2242-52 - PubMed
  56. Clin Obstet Gynecol. 2013 Sep;56(3):537-48 - PubMed
  57. Pediatr Res. 1987 Aug;22(2):192-6 - PubMed
  58. Gen Pharmacol. 2000 Aug;35(2):107-18 - PubMed
  59. Comp Biochem Physiol A Mol Integr Physiol. 1998 Mar;119(3):683-94 - PubMed
  60. Am J Physiol. 1994 Aug;267(2 Pt 2):H757-63 - PubMed
  61. Am J Dis Child. 1970 Jun;119(6):529-42 - PubMed
  62. Am J Obstet Gynecol. 1981 Feb 15;139(4):365-72 - PubMed
  63. Mead Johnson Symp Perinat Dev Med. 1980;(17):17-29 - PubMed
  64. J Physiol. 2009 May 1;587(Pt 9):2033-47 - PubMed
  65. Pediatr Res. 2000 Mar;47(3):369-75 - PubMed
  66. Pediatr Res. 1986 Oct;20(10):973-6 - PubMed
  67. Circ Res. 1985 Nov;57(5):689-94 - PubMed
  68. Pediatr Clin North Am. 1982 Oct;29(5):1077-1104 - PubMed
  69. Arch Physiol Biochem. 2003 Feb;111(1):36-44 - PubMed
  70. Dev Neurosci. 2001;23(3):224-33 - PubMed
  71. Am J Physiol. 1997 May;272(5 Pt 2):H2271-81 - PubMed
  72. Am J Physiol Cell Physiol. 2001 Dec;281(6):C1785-96 - PubMed
  73. PLoS One. 2013 Dec 18;8(12):e82200 - PubMed
  74. Am J Physiol. 1997 Oct;273(4):R1367-73 - PubMed
  75. J Appl Physiol (1985). 2002 Apr;92(4):1692-701 - PubMed
  76. Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R737-44 - PubMed
  77. Jpn J Pharmacol. 1974;24(0):s:68 - PubMed
  78. Int Anesthesiol Clin. 1976 Fall;14(3):165-204 - PubMed
  79. Blood Vessels. 1977;14(1):12-24 - PubMed
  80. J Appl Physiol (1985). 2009 Oct;107(4):1223-34 - PubMed
  81. Am J Physiol Heart Circ Physiol. 2003 Aug;285(2):H701-9 - PubMed
  82. Biol Neonate. 1988;53(5):279-89 - PubMed
  83. Pediatr Res. 1982 Feb;16(2):137-40 - PubMed
  84. J Appl Physiol (1985). 2006 Jun;100(6):1857-66 - PubMed
  85. J Pharmacol Exp Ther. 1985 Jun;233(3):628-35 - PubMed
  86. Biol Neonate. 1998;74(3):222-32 - PubMed
  87. Pediatr Res. 2005 Jun;57(6):873-8 - PubMed
  88. Am J Physiol Regul Integr Comp Physiol. 2012 Feb 15;302(4):R433-45 - PubMed
  89. Pediatr Res. 1980 Oct;14(10):1104-10 - PubMed
  90. Am J Physiol Heart Circ Physiol. 2000 Aug;279(2):H502-10 - PubMed
  91. Brain Res. 1995 Aug 7;688(1-2):61-71 - PubMed
  92. Am J Physiol. 1993 Jan;264(1 Pt 2):R65-72 - PubMed
  93. J Physiol. 2003 Feb 1;546(Pt 3):869-78 - PubMed
  94. J Physiol. 2004 Jul 15;558(Pt 2):623-32 - PubMed
  95. Biol Neonate. 1998;74(1):60-71 - PubMed
  96. J Appl Physiol (1985). 1995 Sep;79(3):831-7 - PubMed
  97. Am J Physiol. 1999 Jul;277(1):R286-94 - PubMed
  98. Am J Physiol. 1991 Aug;261(2 Pt 2):R458-65 - PubMed
  99. Brain Res Dev Brain Res. 1993 Nov 19;76(1):131-40 - PubMed
  100. Trends Biochem Sci. 2006 Apr;31(4):231-9 - PubMed
  101. Biol Neonate. 1975;26(5-6):301-17 - PubMed
  102. Biol Neonate. 2006;90(1):1-8 - PubMed
  103. Am J Physiol. 1992 Jan;262(1 Pt 2):R137-43 - PubMed
  104. Pediatr Res. 1983 Apr;17(4):246-9 - PubMed
  105. Am J Physiol Regul Integr Comp Physiol. 2000 Sep;279(3):R860-73 - PubMed
  106. Annu Rev Med. 1968;19:195-206 - PubMed
  107. Neurol Clin. 1985 Feb;3(1):31-46 - PubMed
  108. Am J Physiol Regul Integr Comp Physiol. 2003 Mar;284(3):R734-41 - PubMed
  109. Pediatr Res. 1984 Dec;18(12):1309-16 - PubMed
  110. Am J Physiol Regul Integr Comp Physiol. 2010 May;298(5):R1366-74 - PubMed
  111. Pediatr Res. 1985 Feb;19(2):159-61 - PubMed
  112. Circ Res. 1977 Dec;41(6):844-8 - PubMed
  113. Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H414-25 - PubMed
  114. Am J Physiol. 1975 Feb;228(2):337-44 - PubMed
  115. Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1797-806 - PubMed
  116. Am J Obstet Gynecol. 2007 Apr;196(4):359.e1-5 - PubMed
  117. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H548-56 - PubMed
  118. Am J Physiol Heart Circ Physiol. 2008 Dec;295(6):H2289-98 - PubMed
  119. Am J Physiol. 1997 Jun;272(6 Pt 2):R1954-9 - PubMed
  120. J Physiol. 2004 Aug 1;558(Pt 3):883-96 - PubMed
  121. Br J Obstet Gynaecol. 1997 Jun;104(6):652-62 - PubMed
  122. Am J Physiol. 1994 Mar;266(3 Pt 2):R765-72 - PubMed
  123. Am J Physiol Regul Integr Comp Physiol. 2013 May 1;304(9):R734-43 - PubMed
  124. J Appl Physiol (1985). 2006 Feb;100(2):731-8 - PubMed
  125. Neurology. 1979 May;29(5):632-5 - PubMed
  126. Am J Physiol Regul Integr Comp Physiol. 2005 Jan;288(1):R149-57 - PubMed
  127. Adv Exp Med Biol. 2006;578:87-92 - PubMed
  128. Brain Res. 2000 Jan 3;852(1):16-27 - PubMed
  129. Semin Perinatol. 1991 Feb;15(1):40-8 - PubMed
  130. Am J Physiol Regul Integr Comp Physiol. 2000 Dec;279(6):R2004-14 - PubMed
  131. Pediatr Res. 1994 Jul;36(1 Pt 1):25-33 - PubMed
  132. Proc West Pharmacol Soc. 1993;36:71-5 - PubMed
  133. Biol Neonate. 1984;45(2):58-68 - PubMed
  134. Biol Res Nurs. 2006 Oct;8(2):97-103 - PubMed
  135. Proc West Pharmacol Soc. 1993;36:63-70 - PubMed
  136. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):692-6 - PubMed
  137. Am J Physiol Regul Integr Comp Physiol. 2000 Oct;279(4):R1419-29 - PubMed
  138. Pediatr Res. 1985 Nov;19(11):1210-4 - PubMed
  139. Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2183-92 - PubMed
  140. N Engl J Med. 1981 Apr 9;304(15):886-91 - PubMed
  141. Pediatr Res. 1985 Nov;19(11):1160-4 - PubMed
  142. Am J Physiol. 1998 Sep;275(3):H930-9 - PubMed
  143. Neurol Clin. 1985 Feb;3(1):59-75 - PubMed
  144. Am J Physiol. 1996 Dec;271(6 Pt 2):H2313-9 - PubMed
  145. Am J Physiol Cell Physiol. 2013 Apr 1;304(7):C656-65 - PubMed
  146. Pediatr Res. 2012 Aug;72(2):137-46 - PubMed
  147. Semin Perinatol. 1984 Jul;8(3):205-16 - PubMed
  148. Proc West Pharmacol Soc. 1991;34:239-45 - PubMed
  149. Reprod Sci. 2007 Sep;14(6):588-94 - PubMed
  150. Am J Physiol Cell Physiol. 2011 Sep;301(3):C653-66 - PubMed

MeSH terms

Publication Types

Grant support