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Warner MR, Levy MN. Sinus and atrioventricular nodal distribution of sympathetic fibers that contain neuropeptide Y. Circ Res. 1990;67(3):713-21doi: 10.1161/01.res.67.3.713.
Warner, M. R., & Levy, M. N. (1990). Sinus and atrioventricular nodal distribution of sympathetic fibers that contain neuropeptide Y. Circulation research, 67(3), 713-21. https://doi.org/10.1161/01.res.67.3.713
Warner, M R, and Levy, M N. "Sinus and atrioventricular nodal distribution of sympathetic fibers that contain neuropeptide Y." Circulation research vol. 67,3 (1990): 713-21. doi: https://doi.org/10.1161/01.res.67.3.713
Warner MR, Levy MN. Sinus and atrioventricular nodal distribution of sympathetic fibers that contain neuropeptide Y. Circ Res. 1990 Sep;67(3):713-21. doi: 10.1161/01.res.67.3.713. PMID: 2397577.
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Circ Res. 1990 Sep;67(3):713-21. doi: 10.1161/01.res.67.3.713.

Sinus and atrioventricular nodal distribution of sympathetic fibers that contain neuropeptide Y.

Circulation research

M R Warner, M N Levy

Affiliations

  1. Mt. Sinai Medical Center, Division of Investigative Medicine, Cleveland, Ohio.

PMID: 2397577 DOI: 10.1161/01.res.67.3.713

Abstract

Neuropeptide Y and norepinephrine are localized in sympathetic nerve terminals throughout the heart. We sought to determine the functional distribution of the neuropeptide Y-containing sympathetic fibers to the sinus and atrioventricular (AV) nodal regions. We recorded cycle length, AV interval, and arterial pressure in 14 anesthetized dogs. We assessed the release of neuropeptide Y from sympathetic nerve terminals by measuring the attenuation of the vagal effects on cycle length and AV interval that occurred after unilateral ansa subclavia stimulation. Three-minute trains of right or left ansa stimulation, each applied at frequencies of 2, 5, and 10 Hz, produced a frequency-dependent inhibition of the vagal effects on cycle length and AV interval. After right ansa stimulation (10 Hz), however, the percent inhibition of the vagal effects on cycle length was 21 +/- 5% greater (p less than 0.001) than the percent inhibition of the vagal effects on AV interval. Conversely, after left ansa stimulation (10 Hz), the percent inhibition of the vagal effects on AV interval was 54 +/- 7% greater (p less than 0.001) than the percent inhibition of the vagal effects on cycle length. The vagal stimulus characteristics (frequency or voltage) did not significantly alter the percent inhibition, nor did the percent inhibition depend on the vagus stimulated (right or left vagus). We conclude that most of the neuropeptide Y-containing sympathetic fibers at the sinus node originate in right-sided ganglia, whereas most of those at the AV node originate in left-sided ganglia.

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