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Cho YN, Lee KO, Jeong J, et al. The role of insulin resistance in diabetic neuropathy in Koreans with type 2 diabetes mellitus: a 6-year follow-up study. Yonsei Med J. 2014;55(3):700-8doi: 10.3349/ymj.2014.55.3.700.
Cho, Y. N., Lee, K. O., Jeong, J., Park, H. J., Kim, S. M., Shin, H. Y., Hong, J. M., Ahn, C. W., & Choi, Y. C. (2014). The role of insulin resistance in diabetic neuropathy in Koreans with type 2 diabetes mellitus: a 6-year follow-up study. Yonsei medical journal, 55(3), 700-8. https://doi.org/10.3349/ymj.2014.55.3.700
Cho, Yu Na, et al. "The role of insulin resistance in diabetic neuropathy in Koreans with type 2 diabetes mellitus: a 6-year follow-up study." Yonsei medical journal vol. 55,3 (2014): 700-8. doi: https://doi.org/10.3349/ymj.2014.55.3.700
Cho YN, Lee KO, Jeong J, Park HJ, Kim SM, Shin HY, Hong JM, Ahn CW, Choi YC. The role of insulin resistance in diabetic neuropathy in Koreans with type 2 diabetes mellitus: a 6-year follow-up study. Yonsei Med J. 2014 May;55(3):700-8. doi: 10.3349/ymj.2014.55.3.700. Epub 2014 Apr 01. PMID: 24719137; PMCID: PMC3990070.
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Yonsei Med J. 2014 May;55(3):700-8. doi: 10.3349/ymj.2014.55.3.700. Epub 2014 Apr 01.

The role of insulin resistance in diabetic neuropathy in Koreans with type 2 diabetes mellitus: a 6-year follow-up study.

Yonsei medical journal

Yu Na Cho, Kee Ook Lee, Julie Jeong, Hyung Jun Park, Seung-Min Kim, Ha Young Shin, Ji-Man Hong, Chul Woo Ahn, Young-Chul Choi

Affiliations

  1. Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
  2. Department of Neurology, Konyang University College of Medicine, Daejeon, Korea.
  3. Department of Neurology, Wonkwang University College of Medicine, Gunpo, Korea.
  4. Department of Neurology, Ewha Womans University College of Medicine, Seoul, Korea.
  5. Department of Neurology, Yonsei University College of Medicine, Yongin, Korea.
  6. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

PMID: 24719137 PMCID: PMC3990070 DOI: 10.3349/ymj.2014.55.3.700

Abstract

PURPOSE: We previously reported that insulin resistance, low high-density lipoprotein (HDL) cholesterol, and glycaemic exposure Index are independently associated with peripheral neuropathy in Korean patients with type 2 diabetes mellitus. We followed the patients who participated in that study in 2006 for another 6 years to determine the relationship between insulin resistance and neuropathy.

MATERIALS AND METHODS: This study involved 48 of the original 86 Korean patients with type 2 diabetes mellitus who were referred to the Neurology clinic for the assessment of diabetic neuropathy from January 2006 to December 2006. These 48 patients received management for glycaemic control and prevention of diabetic complications in the outpatient clinic up to 2012. We reviewed blood test results and the nerve conduction study findings of these patients, taken over a 6-year period.

RESULTS: Low HDL cholesterol and high triglycerides significantly influenced the development of diabetic neuropathy. Kitt value (1/insulin resistance) in the previous study affected the occurrence of neuropathy, despite adequate glycaemic control with HbA1c <7%. Insulin resistance affected the development of diabetic neuropathy after 6 years: insulin resistance in 2006 showed a positive correlation with a change in sural sensory nerve action potential in 2012.

CONCLUSION: Diabetic neuropathy can be affected by previous insulin resistance despite regular glycaemic control. Dyslipidaemia should be controlled in patients who show high insulin resistance because HDL cholesterol and triglycerides are strongly correlated with later development of diabetic neuropathy.

Keywords: Insulin resistance; diabetic neuropathy; metabolic syndrome; type 2 diabetes mellitus

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