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Schwartz PJ. Cardiac sympathetic denervation to prevent life-threatening arrhythmias. Nat Rev Cardiol. 2014;11(6):346-53doi: 10.1038/nrcardio.2014.19.
Schwartz, P. J. (2014). Cardiac sympathetic denervation to prevent life-threatening arrhythmias. Nature reviews. Cardiology, 11(6), 346-53. https://doi.org/10.1038/nrcardio.2014.19
Schwartz, Peter J. "Cardiac sympathetic denervation to prevent life-threatening arrhythmias." Nature reviews. Cardiology vol. 11,6 (2014): 346-53. doi: https://doi.org/10.1038/nrcardio.2014.19
Schwartz PJ. Cardiac sympathetic denervation to prevent life-threatening arrhythmias. Nat Rev Cardiol. 2014 Jun;11(6):346-53. doi: 10.1038/nrcardio.2014.19. Epub 2014 Mar 11. PMID: 24614115.
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Nat Rev Cardiol. 2014 Jun;11(6):346-53. doi: 10.1038/nrcardio.2014.19. Epub 2014 Mar 11.

Cardiac sympathetic denervation to prevent life-threatening arrhythmias.

Nature reviews. Cardiology

Peter J Schwartz

Affiliations

  1. Center for Cardiac Arrhythmias of Genetic Origin, IRCCS Istituto Auxologico Italiano, Casa di Cura San Carlo, Via Pier Lombardo 22, 20135 Milan, Italy.

PMID: 24614115 DOI: 10.1038/nrcardio.2014.19

Abstract

Experimental and clinical evidence indicating an antiarrhythmic effect of cardiac sympathetic denervation has been available for 100 years. Experimental data show that left cardiac sympathetic denervation (LCSD), in particular, is not only antiarrhythmic, but also antifibrillatory-an effect exquisitely important for any clinical condition associated with a high risk of ventricular fibrillation and sudden cardiac death. LCSD has additional effects on both the coronary circulation and the mechanical performance of the left ventricle, with important implications for patients with ischaemic cardiomyopathy. Evidence also shows that LCSD increases the vagal activity directed to the heart, which has potential implications for the management of heart failure. In this Review, the current and novel clinical indications for LCSD are discussed, particularly in the context of results obtained in patients with channelopathies, such as long QT syndrome and catecholaminergic polymorphic ventricular tachycardia.

References

  1. Circulation. 1980 Dec;62(6):1256-65 - PubMed
  2. Circ Res. 1991 Nov;69(5):1389-401 - PubMed
  3. Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1171-93 - PubMed
  4. N Engl J Med. 2008 May 8;358(19):2024-9 - PubMed
  5. Ann Surg. 1925 Mar;81(3):591-604 - PubMed
  6. Circulation. 1984 Apr;69(4):790-800 - PubMed
  7. Int J Neuropharmacol. 1964 Apr;3:65-9 - PubMed
  8. Ann Thorac Surg. 2008 Nov;86(5):1620-5 - PubMed
  9. Heart Rhythm. 2009 Jun;6(6):752-9 - PubMed
  10. Eur Heart J. 2013 Oct;34(40):3109-16 - PubMed
  11. Circulation. 2010 Jun 1;121(21):2255-62 - PubMed
  12. Circ Res. 1973 Feb;32(2):215-20 - PubMed
  13. Am Heart J. 1955 Oct;50(4):483-91 - PubMed
  14. Heart Rhythm. 2010 Aug;7(8):1161-5 - PubMed
  15. J Neurosurg. 1947 Jan;4(1):19-39 - PubMed
  16. Am J Physiol. 1951 Jun;165(3):505-12 - PubMed
  17. J Thorac Cardiovasc Surg. 1962 Jul;44:90-6 - PubMed
  18. Eur Heart J. 2011 Apr;32(7):847-55 - PubMed
  19. J Am Coll Cardiol. 2010 Jun 15;55(24):2769-77 - PubMed
  20. N Engl J Med. 1971 Oct 14;285(16):903-4 - PubMed
  21. Heart Fail Rev. 2011 Mar;16(2):101-7 - PubMed
  22. Am J Cardiol. 1979 Feb;43(2):313-28 - PubMed
  23. J Physiol. 1973 Mar;229(2):457-69 - PubMed
  24. Circ Res. 1977 Jun;40(6):536-40 - PubMed
  25. Circ Res. 1956 Jul;4(4):470-5 - PubMed
  26. J Am Med Assoc. 1956 Oct 20;162(8):709-12 - PubMed
  27. Cardiovasc Res. 1970 Apr;4(2):141-7 - PubMed
  28. J Am Coll Cardiol. 2012 Jan 3;59(1):91-2 - PubMed
  29. Ann Intern Med. 1968 Mar;68(3):591-7 - PubMed
  30. Am Heart J. 1976 Nov;92(5):589-99 - PubMed
  31. Am Heart J. 1975 Mar;89(3):378-90 - PubMed
  32. Circ Res. 1979 May;44(5):637-45 - PubMed
  33. Circ Res. 1966 Apr;18(4):416-28 - PubMed
  34. Cardiovasc Res. 1969 Jul;3(3):241-4 - PubMed
  35. Circulation. 1988 Oct;78(4):969-79 - PubMed
  36. Am J Cardiol. 1976 Jun;37(7):1034-40 - PubMed
  37. Am J Cardiol. 1982 Apr 1;49(5):1185-90 - PubMed
  38. J Clin Invest. 1956 Jun;35(6):649-56 - PubMed
  39. Circ Arrhythm Electrophysiol. 2012 Aug 1;5(4):782-8 - PubMed
  40. Circulation. 1982 Oct;66(4):874-80 - PubMed
  41. Heart Rhythm. 2014 Jan;11(1):58-66 - PubMed
  42. Eur Heart J. 1991 Oct;12(10):1112-31 - PubMed
  43. Am J Cardiol. 1985 Sep 1;56(7):384-9 - PubMed
  44. Circulation. 2001 Apr 24;103(16):2072-7 - PubMed
  45. Am J Med Sci. 1966 Sep;252(3):289-95 - PubMed
  46. Lancet. 1998 Feb 14;351(9101):478-84 - PubMed
  47. Heart Rhythm. 2013 Apr;10(4):542-7 - PubMed
  48. Am Heart J. 1974 Dec;88(6):748-57 - PubMed
  49. Circulation. 1991 Aug;84(2):503-11 - PubMed
  50. Eur J Heart Fail. 2012 Dec;14(12):1316-8 - PubMed
  51. Am Heart J. 1985 May;109(5 Pt 1):937-48 - PubMed
  52. Ann N Y Acad Sci. 1984;427:199-221 - PubMed
  53. Am J Med. 1961 Sep;31:493-7 - PubMed
  54. Heart Rhythm. 2010 Sep;7(9):1330-2 - PubMed
  55. Heart Rhythm. 2014 Mar;11(3):360-6 - PubMed
  56. Circ Res. 1991 May;68(5):1471-81 - PubMed
  57. Circulation. 2004 Apr 20;109(15):1826-33 - PubMed
  58. J Cardiovasc Transl Res. 2014 Apr;7(3):338-46 - PubMed
  59. Am Heart J. 1975 Jan;89(1):45-50 - PubMed
  60. Am Heart J. 1985 Feb;109(2):399-411 - PubMed
  61. Heart Rhythm. 2009 Jun;6(6):760-3 - PubMed
  62. J Electrocardiol. 1971;4(1):34-43 - PubMed
  63. Eur J Heart Fail. 2008 Sep;10(9):884-91 - PubMed
  64. J Cardiovasc Pharmacol. 1981 Nov-Dec;3(6):1251-9 - PubMed

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