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Eason BD, Fine DM, Leeder D, et al. Influence of beta blockers on survival in dogs with severe subaortic stenosis. J Vet Intern Med. 2014;28(3):857-62doi: 10.1111/jvim.12339.
Eason, B. D., Fine, D. M., Leeder, D., Stauthammer, C., Lamb, K., & Tobias, A. H. (2014). Influence of beta blockers on survival in dogs with severe subaortic stenosis. Journal of veterinary internal medicine, 28(3), 857-62. https://doi.org/10.1111/jvim.12339
Eason, B D, et al. "Influence of beta blockers on survival in dogs with severe subaortic stenosis." Journal of veterinary internal medicine vol. 28,3 (2014): 857-62. doi: https://doi.org/10.1111/jvim.12339
Eason BD, Fine DM, Leeder D, Stauthammer C, Lamb K, Tobias AH. Influence of beta blockers on survival in dogs with severe subaortic stenosis. J Vet Intern Med. 2014 May-Jun;28(3):857-62. doi: 10.1111/jvim.12339. Epub 2014 Mar 05. PMID: 24597738; PMCID: PMC4895480.
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J Vet Intern Med. 2014 May-Jun;28(3):857-62. doi: 10.1111/jvim.12339. Epub 2014 Mar 05.

Influence of beta blockers on survival in dogs with severe subaortic stenosis.

Journal of veterinary internal medicine

B D Eason, D M Fine, D Leeder, C Stauthammer, K Lamb, A H Tobias

Affiliations

  1. College of Veterinary Medicine, University of Missouri, Columbia, MO.

PMID: 24597738 PMCID: PMC4895480 DOI: 10.1111/jvim.12339

Abstract

BACKGROUND: Subaortic stenosis (SAS) is one of the most common congenital cardiac defects in dogs. Severe SAS frequently is treated with a beta adrenergic receptor blocker (beta blocker), but this approach largely is empirical.

OBJECTIVE: To determine the influence of beta blocker treatment on survival time in dogs with severe SAS.

METHODS: Retrospective review of medical records of dogs diagnosed with severe, uncomplicated SAS (pressure gradient [PG] ≥80 mmHg) between 1999 and 2011.

RESULTS: Fifty dogs met the inclusion criteria. Twenty-seven dogs were treated with a beta blocker and 23 received no treatment. Median age at diagnosis was significantly greater in the untreated group (1.2 versus 0.6 years, respectively; P = .03). Median PG at diagnosis did not differ between the treated and untreated groups (127 versus 121 mmHg, respectively; P = .2). Cox proportional hazards regression was used to identify the influence of PG at diagnosis, age at diagnosis, and beta blocker treatment on survival. In the all-cause multivariate mortality analysis, only age at diagnosis (P = .02) and PG at diagnosis (P = .03) affected survival time. In the cardiac mortality analysis, only PG influenced survival time (P = .03). Treatment with a beta blocker did not influence survival time in either the all-cause (P = .93) or cardiac-cause (P = .97) mortality analyses.

CONCLUSIONS: Beta blocker treatment did not influence survival in dogs with severe SAS in our study, and a higher PG at diagnosis was associated with increased risk of death.

Copyright © 2014 by the American College of Veterinary Internal Medicine.

Keywords: Atenolol; Congenital heart disease

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