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J Cardiovasc Transl Res. 2014 Apr;7(3):310-20. doi: 10.1007/s12265-014-9540-1. Epub 2014 Feb 06.

Vagal stimulation in heart failure.

Journal of cardiovascular translational research

Gaetano M De Ferrari

Affiliations

  1. Department of Cardiology, Fondazione IRCCS Policlinico San Matteo, Viale Golgi, 19, 27100, Pavia, Italy, [email protected].

PMID: 24500409 DOI: 10.1007/s12265-014-9540-1

Abstract

Heart failure (HF) is accompanied by an autonomic imbalance that is almost always characterized by both increased sympathetic activity and withdrawal of vagal activity. Experimentally, vagal stimulation has been shown to exert profound antiarrhythmic activity and to improve cardiac function and survival in HF models. A open-label pilot clinical study in 32 patients with chronic HF has shown safety and tolerability of chronic vagal stimulation associated with subjective (improved quality of life and 6-min walk test) and objective improvements (reduced left ventricular systolic volumes and improved left ventricular ejection fraction). Three larger clinical studies, including a phase III trial are currently ongoing and will evaluate the clinical role of this new approach.

References

  1. Circulation. 1986 Nov;74(5):1124-36 - PubMed
  2. J Am Coll Cardiol. 1996 Feb;27(2):358-64 - PubMed
  3. Crit Care Med. 2005 Nov;33(11):2621-8 - PubMed
  4. Nature. 2002 Dec 19-26;420(6917):853-9 - PubMed
  5. Lancet. 1998 Feb 14;351(9101):478-84 - PubMed
  6. Eur J Heart Fail. 2011 Aug;13(8):825-9 - PubMed
  7. Eur J Heart Fail. 2013 Dec;15(12):1319-26 - PubMed
  8. Circ Res. 1973 Feb;32(2):215-20 - PubMed
  9. Am Heart J. 1977 Jan;93(1):60-5 - PubMed
  10. Eur Heart J. 2011 Apr;32(7):847-55 - PubMed
  11. Eur J Heart Fail. 2014 Jun;16(6):692-9 - PubMed
  12. J Am Coll Cardiol. 1993 Jul;22(1):283-90 - PubMed
  13. Exp Physiol. 2013 Feb;98(2):425-34 - PubMed
  14. Circulation. 1997 Nov 18;96(10):3450-8 - PubMed
  15. J Neural Eng. 2011 Jun;8(3):034004 - PubMed
  16. Heart Fail Rev. 2011 Mar;16(2):129-35 - PubMed
  17. J Electrocardiol. 1978 Jan;11(1):27-31 - PubMed
  18. Circulation. 2001 Mar 13;103(10):1428-33 - PubMed
  19. Circ Heart Fail. 2009 Nov;2(6):692-9 - PubMed
  20. Circulation. 1980 Jan;61(1):175-82 - PubMed
  21. Circulation. 1974 May;49(5):943-7 - PubMed
  22. Mol Med. 2007 Mar-Apr;13(3-4):178-84 - PubMed
  23. Am J Cardiol. 1987 Feb 1;59(4):256-62 - PubMed
  24. Am J Cardiol. 1992 Dec 15;70(20):1640-2 - PubMed
  25. Circulation. 2005 Jul 12;112(2):164-70 - PubMed
  26. Heart Fail Rev. 2011 Mar;16(2):195-203 - PubMed
  27. J Am Coll Cardiol. 2007 Dec 11;50(24):2285-90 - PubMed
  28. Heart Fail Rev. 2011 Mar;16(2):171-8 - PubMed
  29. Circulation. 1988 Oct;78(4):969-79 - PubMed
  30. Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H237-42 - PubMed
  31. Basic Res Cardiol. 2013 May;108(3):345 - PubMed
  32. Heart Rhythm. 2013 Nov;10(11):1700-7 - PubMed
  33. Circulation. 2004 Jan 6;109(1):120-4 - PubMed
  34. J Card Fail. 2010 Aug;16(8):689-99 - PubMed
  35. Lancet. 2010 Sep 11;376(9744):875-85 - PubMed
  36. Lancet. 2010 Sep 11;376(9744):886-94 - PubMed
  37. Neurology. 2002 Sep 24;59(6 Suppl 4):S15-20 - PubMed
  38. Circ Res. 1975 Apr;36(4):529-35 - PubMed
  39. Circ Res. 1987 Sep;61(3):429-35 - PubMed
  40. Heart Fail Rev. 2011 Mar;16(2):137-45 - PubMed
  41. J Neural Eng. 2013 Apr;10(2):026003 - PubMed
  42. J Am Coll Cardiol. 2009 Jul 28;54(5):375-85 - PubMed
  43. Lancet. 1999 Apr 24;353(9162):1390-6 - PubMed
  44. J Clin Neurophysiol. 2001 Sep;18(5):415-8 - PubMed
  45. Circulation. 1982 Oct;66(4):874-80 - PubMed
  46. Am Heart J. 2012 Jun;163(6):954-962.e1 - PubMed
  47. PLoS One. 2012;7(11):e42799 - PubMed
  48. Circulation. 1975 Oct;52(4):578-85 - PubMed
  49. J Card Fail. 2013 Sep;19(9):655-60 - PubMed
  50. J Cell Mol Med. 2013 May;17(5):664-71 - PubMed
  51. JACC Cardiovasc Interv. 2013 Oct;6(10):1055-63 - PubMed
  52. Heart Fail Rev. 2013 Jul;18(4):389-408 - PubMed
  53. Circ Res. 1991 May;68(5):1471-81 - PubMed
  54. Am J Physiol. 1991 Jul;261(1 Pt 2):H63-9 - PubMed
  55. J Thorac Cardiovasc Surg. 2009 Jan;137(1):223-31 - PubMed
  56. Am J Cardiol. 1992 Feb 15;69(5):523-31 - PubMed
  57. Circulation. 2009 Apr 14;119(14):e391-479 - PubMed
  58. Cardiovasc Res. 2008 Mar 1;77(4):713-21 - PubMed
  59. Am J Physiol. 1970 Dec;219(6):1665-71 - PubMed
  60. N Engl J Med. 2007 Sep 13;357(11):1121-35 - PubMed
  61. J Cardiovasc Pharmacol. 2011 Nov;58(5):500-7 - PubMed
  62. Circulation. 2004 Oct 19;110(16):2389-94 - PubMed
  63. FEBS Lett. 2005 Apr 11;579(10):2111-8 - PubMed
  64. J Am Coll Cardiol. 2009 Jan 13;53(2):193-9 - PubMed
  65. J Cardiovasc Pharmacol. 1990 Apr;15(4):586-91 - PubMed
  66. Circulation. 2008 Aug 19;118(8):863-71 - PubMed
  67. Med Hypotheses. 2013 Nov;81(5):905-7 - PubMed
  68. N Engl J Med. 1971 Oct 14;285(16):877-83 - PubMed
  69. Eur J Heart Fail. 2008 Sep;10(9):884-91 - PubMed
  70. Circulation. 1973 Feb;47(2):291-8 - PubMed
  71. Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2606-11 - PubMed
  72. Am J Physiol. 1991 Apr;260(4 Pt 2):H1379-84 - PubMed

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