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Cote RJ, Rosenblum M, Telzak EE, et al. Disseminated Pneumocystis carinii infection causing extrapulmonary organ failure: clinical, pathologic, and immunohistochemical analysis. Mod Pathol. 1990;3(1):25-30
Cote, R. J., Rosenblum, M., Telzak, E. E., May, M., Unger, P. D., & Cartun, R. W. (1990). Disseminated Pneumocystis carinii infection causing extrapulmonary organ failure: clinical, pathologic, and immunohistochemical analysis. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 3(1), 25-30.
Cote, R J, et al. "Disseminated Pneumocystis carinii infection causing extrapulmonary organ failure: clinical, pathologic, and immunohistochemical analysis." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 3,1 (1990): 25-30.
Cote RJ, Rosenblum M, Telzak EE, May M, Unger PD, Cartun RW. Disseminated Pneumocystis carinii infection causing extrapulmonary organ failure: clinical, pathologic, and immunohistochemical analysis. Mod Pathol. 1990 Jan;3(1):25-30. PMID: 2308917.
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Mod Pathol. 1990 Jan;3(1):25-30.

Disseminated Pneumocystis carinii infection causing extrapulmonary organ failure: clinical, pathologic, and immunohistochemical analysis.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

R J Cote, M Rosenblum, E E Telzak, M May, P D Unger, R W Cartun

Affiliations

  1. Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York.

PMID: 2308917

Abstract

Pneumocystis carinii pneumonia is an important infection in the immunocompromised host, and the rate of symptomatic infections has risen dramatically with the advent of immunosuppressive therapies and infections with the human immunodeficiency virus (HIV). However, dissemination of P. carinii is thought to be an unusual event, and it is rarely suspected of causing extrapulmonary symptomatology. We have recently examined the cases of patients with acquired immunodeficiency syndrome (AIDS) who demonstrated at autopsy extrapulmonary infection with P. carinii. Three of these patients had widespread pneumocystosis, and in one patient dysfunction in several organs could be directly attributed to effects of P. carinii, which contributed to his death. The possible factors leading to dissemination of P. carinii are discussed. We also describe the use of a newly developed monoclonal antibody to P. carinii in detecting extrapulmonary infections.

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