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Ezeama CO, Eleje GU, Ezeama NN, et al. A comparison of prophylactic intramuscular ergometrine and oxytocin for women in the third stage of labor. Int J Gynaecol Obstet. 2013;124(1):67-71doi: 10.1016/j.ijgo.2013.07.020.
Ezeama, C. O., Eleje, G. U., Ezeama, N. N., Igwegbe, A. O., Ikechebelu, J. I., Ugboaja, J. O., Ezebialu, I. U., & Eke, A. C. (2014). A comparison of prophylactic intramuscular ergometrine and oxytocin for women in the third stage of labor. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 124(1), 67-71. https://doi.org/10.1016/j.ijgo.2013.07.020
Ezeama, Chukwuemeka O, et al. "A comparison of prophylactic intramuscular ergometrine and oxytocin for women in the third stage of labor." International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics vol. 124,1 (2014): 67-71. doi: https://doi.org/10.1016/j.ijgo.2013.07.020
Ezeama CO, Eleje GU, Ezeama NN, Igwegbe AO, Ikechebelu JI, Ugboaja JO, Ezebialu IU, Eke AC. A comparison of prophylactic intramuscular ergometrine and oxytocin for women in the third stage of labor. Int J Gynaecol Obstet. 2014 Jan;124(1):67-71. doi: 10.1016/j.ijgo.2013.07.020. Epub 2013 Oct 05. PMID: 24365208.
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Int J Gynaecol Obstet. 2014 Jan;124(1):67-71. doi: 10.1016/j.ijgo.2013.07.020. Epub 2013 Oct 05.

A comparison of prophylactic intramuscular ergometrine and oxytocin for women in the third stage of labor.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Chukwuemeka O Ezeama, George U Eleje, Nkiru N Ezeama, Anthony O Igwegbe, Joseph I Ikechebelu, Joseph O Ugboaja, Ifeanyichukwu U Ezebialu, Ahizechukwu C Eke

Affiliations

  1. Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
  2. Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria. Electronic address: [email protected].
  3. Department of Community Medicine, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
  4. Department of Obstetrics and Gynecology, Anambra State University Teaching Hospital, Awka, Nigeria.
  5. Department of Obstetrics and Gynecology, Michigan State University/Sparrow Hospital, Lansing, USA.

PMID: 24365208 DOI: 10.1016/j.ijgo.2013.07.020

Abstract

OBJECTIVE: To compare the efficacy and adverse effects of ergometrine and oxytocin given intramuscularly for the prevention of postpartum hemorrhage during the third stage of labor.

METHODS: The study included women with a singleton pregnancy of at least 28 weeks' gestation who had a vaginal delivery. High-risk pregnancies were excluded. Oxytocin (10 IU) or ergometrine (0.5mg) were administered intramuscularly in a blinded pattern immediately after delivery of the infant. An intention-to-treat analysis was performed.

RESULTS: Postpartum blood loss (301.8 ± 109.2 mL versus 287.1 ± 84.4 mL, P=0.011) and packed cell volume (30.7 ± 1.7% versus 31.6 ± 2.0%; Z=0.00; P=0.008) were considerably reduced among parturients who received intramuscular ergometrine. The rates of therapeutic oxytocics use, blood transfusion, placental retention, and manual removal of the placenta were significantly higher in the oxytocin group. No significant differences between the groups were observed in terms of adverse effects, with the exception of diastolic hypertension, which was more common in the ergometrine group (odds ratio, 0.00; 95% confidence interval, 0.00-0.75; P=0.007).

CONCLUSION: Intramuscular ergometrine is superior to intramuscular oxytocin in averting postpartum hemorrhage during the third stage of labor. There are no significant risks of adverse effects except for diastolic hypertension.

© 2013.

Keywords: Adverse effects; Diastolic hypertension; Ergometrine; Intramuscular; Oxytocin; Postpartum hemorrhage; Prevention

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