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Zou YF, Zhang BZ, Inngjerdingen KT, et al. Polysaccharides with immunomodulating properties from the bark of Parkia biglobosa. Carbohydr Polym. 2013;101:457-63doi: 10.1016/j.carbpol.2013.09.082.
Zou, Y. F., Zhang, B. Z., Inngjerdingen, K. T., Barsett, H., Diallo, D., Michaelsen, T. E., El-Zoubair, E., & Paulsen, B. S. (2014). Polysaccharides with immunomodulating properties from the bark of Parkia biglobosa. Carbohydrate polymers, 101457-63. https://doi.org/10.1016/j.carbpol.2013.09.082
Zou, Yuan-Feng, et al. "Polysaccharides with immunomodulating properties from the bark of Parkia biglobosa." Carbohydrate polymers vol. 101 (2014): 457-63. doi: https://doi.org/10.1016/j.carbpol.2013.09.082
Zou YF, Zhang BZ, Inngjerdingen KT, Barsett H, Diallo D, Michaelsen TE, El-Zoubair E, Paulsen BS. Polysaccharides with immunomodulating properties from the bark of Parkia biglobosa. Carbohydr Polym. 2014 Jan 30;101:457-63. doi: 10.1016/j.carbpol.2013.09.082. Epub 2013 Sep 30. PMID: 24299798.
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Carbohydr Polym. 2014 Jan 30;101:457-63. doi: 10.1016/j.carbpol.2013.09.082. Epub 2013 Sep 30.

Polysaccharides with immunomodulating properties from the bark of Parkia biglobosa.

Carbohydrate polymers

Yuan-Feng Zou, Bing-Zhao Zhang, Kari Tvete Inngjerdingen, Hilde Barsett, Drissa Diallo, Terje Einar Michaelsen, Elnour El-Zoubair, Berit Smestad Paulsen

Affiliations

  1. Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068, Blindern, 0316 Oslo, Norway. Electronic address: [email protected].

PMID: 24299798 DOI: 10.1016/j.carbpol.2013.09.082

Abstract

The bark of Parkia biglobosa is used in traditional medicine to cure a wide range of illnesses. Polysaccharides were extracted from the bark with 50% ethanol-water, 50°C and 100°C water, and seven active fractions obtained by anion exchange chromatography and gel filtration. The complement fixation and macrophage stimulating activities of the different fractions were determined. The acidic fractions PBEII-I and PBEII-IV were the most active in the complement fixation assay, but the other fractions were also potent compared to the positive control BPII from Biophytum petersianum. Fractions PBEII-I and PBEII-IV were also the most potent fractions in stimulating macrophages to release nitric oxide. Structural studies showed that PBEII-I and PBEII-IV were pectic type polysaccharides, containing arabinogalactan type II structures. The observed differences in biological activities among the seven purified polysaccharide sub-fractions are probably due to differences in monosaccharide compositions, linkage types and molecular sizes.

Copyright © 2013 Elsevier Ltd. All rights reserved.

Keywords: 4-O-methyl-glucuronic acid; 4-OMe-GlcA; AG-I; AG-II; Ara; Complement system; GC–MS; Gal; GalA; Glc; GlcA; Immunomodulation; LPS; Macrophage stimulation; Man; NO; Parkia biglobosa; Pectic polysaccharides; RG-I; RG-II; Rha; Xyl; arabinogalactan type I; arabinogalactan type II; arabinose; galactose; galacturonic acid; gas chromatography–mass spectrometry; glucose; glucuronic acid; lipopolysaccharide; mannose; nitric oxide; rhamnogalacturonan type I; rhamnogalacturonan type II; rhamnose; xylose

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