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Lane JT, Godbole M, Strait KA, et al. Prolonged fasting reduces rat hepatic beta 1 thyroid hormone receptor protein without changing the level of its messenger ribonucleic acid. Endocrinology. 1991;129(6):2881-5doi: 10.1210/endo-129-6-2881.
Lane, J. T., Godbole, M., Strait, K. A., Schwartz, H. L., & Oppenheimer, J. H. (1991). Prolonged fasting reduces rat hepatic beta 1 thyroid hormone receptor protein without changing the level of its messenger ribonucleic acid. Endocrinology, 129(6), 2881-5. https://doi.org/10.1210/endo-129-6-2881
Lane, J T, et al. "Prolonged fasting reduces rat hepatic beta 1 thyroid hormone receptor protein without changing the level of its messenger ribonucleic acid." Endocrinology vol. 129,6 (1991): 2881-5. doi: https://doi.org/10.1210/endo-129-6-2881
Lane JT, Godbole M, Strait KA, Schwartz HL, Oppenheimer JH. Prolonged fasting reduces rat hepatic beta 1 thyroid hormone receptor protein without changing the level of its messenger ribonucleic acid. Endocrinology. 1991 Dec;129(6):2881-5. doi: 10.1210/endo-129-6-2881. PMID: 1720087.
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Endocrinology. 1991 Dec;129(6):2881-5. doi: 10.1210/endo-129-6-2881.

Prolonged fasting reduces rat hepatic beta 1 thyroid hormone receptor protein without changing the level of its messenger ribonucleic acid.

Endocrinology

J T Lane, M Godbole, K A Strait, H L Schwartz, J H Oppenheimer

Affiliations

  1. Department of Medicine, University of Minnesota, Minneapolis 55455.

PMID: 1720087 DOI: 10.1210/endo-129-6-2881

Abstract

The level of hepatic nuclear T3-binding capacity falls in rats subjected to fasting. To define the mechanism underlying these changes, we have assayed in liver the concentration of the mRNA coding for the beta 1-receptor (beta 1-TR) isoform, the total nuclear T3-binding capacity, and the fraction of the total binding capacity that can be specifically immunoprecipitated with an anti-beta 1-TR immunoglobulin G preparation. Although no changes in beta 1-TR mRNA concentration were noted, we observed a 60% fall in total binding capacity. beta 1-TR mRNA levels were preserved despite a 50% fall in total poly(A)+ RNA. The fall in beta 1-TR protein, however, was consistent with a generalized decrease in total hepatic protein content. This study provides yet another instance in which measurement of receptor mRNA is not consonant with the behavior of the nuclear T3 receptor protein.

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