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de Graeff-Meeder ER, Voorhorst M, van Eden W, et al. Antibodies to the mycobacterial 65-kd heat-shock protein are reactive with synovial tissue of adjuvant arthritic rats and patients with rheumatoid arthritis and osteoarthritis. Am J Pathol. 1990;137(5):1013-7
de Graeff-Meeder, E. R., Voorhorst, M., van Eden, W., Schuurman, H. J., Huber, J., Barkley, D., Maini, R. N., Kuis, W., Rijkers, G. T., & Zegers, B. J. (1990). Antibodies to the mycobacterial 65-kd heat-shock protein are reactive with synovial tissue of adjuvant arthritic rats and patients with rheumatoid arthritis and osteoarthritis. The American journal of pathology, 137(5), 1013-7.
de Graeff-Meeder, E R, et al. "Antibodies to the mycobacterial 65-kd heat-shock protein are reactive with synovial tissue of adjuvant arthritic rats and patients with rheumatoid arthritis and osteoarthritis." The American journal of pathology vol. 137,5 (1990): 1013-7.
de Graeff-Meeder ER, Voorhorst M, van Eden W, Schuurman HJ, Huber J, Barkley D, Maini RN, Kuis W, Rijkers GT, Zegers BJ. Antibodies to the mycobacterial 65-kd heat-shock protein are reactive with synovial tissue of adjuvant arthritic rats and patients with rheumatoid arthritis and osteoarthritis. Am J Pathol. 1990 Nov;137(5):1013-7. PMID: 1700613; PMCID: PMC1877661.
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Am J Pathol. 1990 Nov;137(5):1013-7.

Antibodies to the mycobacterial 65-kd heat-shock protein are reactive with synovial tissue of adjuvant arthritic rats and patients with rheumatoid arthritis and osteoarthritis.

The American journal of pathology

E R de Graeff-Meeder, M Voorhorst, W van Eden, H J Schuurman, J Huber, D Barkley, R N Maini, W Kuis, G T Rijkers, B J Zegers

Affiliations

  1. Department of Immunology, Wilhelmina Children's Hospital, Utrecht, The Netherlands.

PMID: 1700613 PMCID: PMC1877661
Free PMC Article

Abstract

The expression of 65-kd mycobacterial heat-shock protein (HSP)-related antigens in synovial membrane from rats and humans with arthritis was studied using three monoclonal antibodies and one polyclonal antiserum directed to antigens of mycobacteria. The antibodies labeled synovial tissue sections from both adjuvant arthritis (AA) rats and from patients with either rheumatoid arthritis (RA) or osteoarthritis (OA); especially the synovial lining cells appeared to be positive. The cytoplasmic staining patterns in rats and humans were essentially the same and were not related to the extent of inflammation ie, the size of lymphoid infiltration. In control tissues no cytoplasmic staining was observed. The results suggest a role for a 65-kd HSP or a cross-reactive molecule in the immunopathologic process of arthritic disease.

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