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Cheng SH, Espino PC, Marshall J, et al. Stoichiometry of cellular and viral components in the polyomavirus middle-T antigen-tyrosine kinase complex. Mol Cell Biol. 1990;10(10):5569-74doi: 10.1128/mcb.10.10.5569-5574.1990.
Cheng, S. H., Espino, P. C., Marshall, J., Harvey, R., & Smith, A. E. (1990). Stoichiometry of cellular and viral components in the polyomavirus middle-T antigen-tyrosine kinase complex. Molecular and cellular biology, 10(10), 5569-74. https://doi.org/10.1128/mcb.10.10.5569-5574.1990
Cheng, S H, et al. "Stoichiometry of cellular and viral components in the polyomavirus middle-T antigen-tyrosine kinase complex." Molecular and cellular biology vol. 10,10 (1990): 5569-74. doi: https://doi.org/10.1128/mcb.10.10.5569-5574.1990
Cheng SH, Espino PC, Marshall J, Harvey R, Smith AE. Stoichiometry of cellular and viral components in the polyomavirus middle-T antigen-tyrosine kinase complex. Mol Cell Biol. 1990 Oct;10(10):5569-74. doi: 10.1128/mcb.10.10.5569-5574.1990. PMID: 1697932; PMCID: PMC361277.
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Atypon Free PMC Article

Mol Cell Biol. 1990 Oct;10(10):5569-74. doi: 10.1128/mcb.10.10.5569-5574.1990.

Stoichiometry of cellular and viral components in the polyomavirus middle-T antigen-tyrosine kinase complex.

Molecular and cellular biology

S H Cheng, P C Espino, J Marshall, R Harvey, A E Smith

Affiliations

  1. Laboratory of Cellular Regulation, Genzyme Corporation, Framingham, Massachusetts 01701.

PMID: 1697932 PMCID: PMC361277 DOI: 10.1128/mcb.10.10.5569-5574.1990
Free PMC Article

Abstract

Our results indicate that only one type of tyrosine kinase is present within each middle-T antigen-tyrosine kinase complex, suggesting that middle-T antigen forms separate complexes with different tyrosine kinases. Furthermore, we determined that there is only one molecule of middle-T antigen within any one of these complexes. We interpret this to mean that in any given cell, polyomavirus transformation involves, at least in part, the simultaneous deregulation of a number of separate pathways controlling cellular proliferation. Finally, we also demonstrate that the separate middle-T:pp60c-src and middle-T:pp59c-fyn complexes are each able to interact with the same cellular p81/85-kDa phosphoprotein, a possible component of the phosphatidylinositol kinase.

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