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Xia Y, Brown L, Yang CY, et al. TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. Proc Natl Acad Sci U S A. 1991;88(24):11416-20doi: 10.1073/pnas.88.24.11416.
Xia, Y., Brown, L., Yang, C. Y., Tsan, J. T., Siciliano, M. J., Espinosa, R., Le Beau, M. M., & Baer, R. J. (1991). TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. Proceedings of the National Academy of Sciences of the United States of America, 88(24), 11416-20. https://doi.org/10.1073/pnas.88.24.11416
Xia, Y, et al. "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia." Proceedings of the National Academy of Sciences of the United States of America vol. 88,24 (1991): 11416-20. doi: https://doi.org/10.1073/pnas.88.24.11416
Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R, Le Beau MM, Baer RJ. TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11416-20. doi: 10.1073/pnas.88.24.11416. PMID: 1763056; PMCID: PMC53146.
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Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11416-20. doi: 10.1073/pnas.88.24.11416.

TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia.

Proceedings of the National Academy of Sciences of the United States of America

Y Xia, L Brown, C Y Yang, J T Tsan, M J Siciliano, R Espinosa, M M Le Beau, R J Baer

Affiliations

  1. Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235.

PMID: 1763056 PMCID: PMC53146 DOI: 10.1073/pnas.88.24.11416
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Abstract

Tumor-specific alteration of the TAL1 gene occurs in almost 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL). We now report the identification of TAL2, a distinct gene that was isolated on the basis of its sequence homology with TAL1. The TAL2 gene is located 33 kilobase pairs from the chromosome 9 breakpoint of t(7;9)(q34;q32), a recurring translocation specifically associated with T-ALL. As a consequence of t(7;9)(q34;q32), TAL2 is juxtaposed with sequences from the T-cell receptor beta-chain gene on chromosome 7. TAL2 sequences are actively transcribed in SUP-T3, a T-ALL cell line that harbors the t(7;9)(q34;q32). The TAL2 gene product includes a helix-loop-helix protein dimerization and DNA binding domain that is especially homologous to those encoded by the TAL1 and LYL1 protooncogenes. Hence, TAL2, TAL1, and LYL1 constitute a discrete subgroup of helix-loop-helix proteins, each of which can potentially contribute to the development of T-ALL.

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