Display options
Share it on

J Natl Cancer Inst. 2013 Oct 02;105(19):1432-40. doi: 10.1093/jnci/djt242. Epub 2013 Sep 18.

Recommendations for high-priority research on cancer-related fatigue in children and adults.

Journal of the National Cancer Institute

Andrea M Barsevick, Michael R Irwin, Pamela Hinds, Andrew Miller, Ann Berger, Paul Jacobsen, Sonia Ancoli-Israel, Bryce B Reeve, Karen Mustian, Ann O'Mara, Jin-Shei Lai, Michael Fisch, David Cella,

Affiliations

  1. Affiliations of authors: Thomas Jefferson University, Philadelphia, PA (AMB); University of California-Los Angeles, Los Angeles, CA (MRI); Children's National Medical Center, Washington, DC (PH); Emory University, Atlanta, GA (AM); University of Nebraska Medical Center, Omaha, NE (AB); Moffitt Cancer Center, Tampa, FL (PJ); University of California-San Diego, San Diego, CA (SA-I); University of North Carolina at Chapel Hill, Chapel Hill, NC (RBR); University of Rochester, Rochester, NY (KM); National Cancer Institute, Bethesda, MD (AOM); Northwestern University, Chicago, IL (J-SL, DC); M.D. Anderson Cancer Center, Houston, TX (MF).

PMID: 24047960 PMCID: PMC3888121 DOI: 10.1093/jnci/djt242

Abstract

Over the past decades, some scientific progress has been made in understanding and treating cancer-related fatigue (CRF). However, three major problems have limited further progress: lack of agreement about measurement, inadequate understanding of the underlying biology, and problems in the conduct of clinical trials for CRF. This commentary reports the recommendations of a National Cancer Institute Clinical Trials Planning Meeting and an ongoing National Cancer Institute working group to address these problems so that high-priority research and clinical trials can be conducted to advance the science of CRF and its treatment. Recommendations to address measurement issues included revising the current case definition to reflect more rigorous criteria, adopting the Patient Reported Outcomes Measurement Information System fatigue scales as standard measures of CRF, and linking legacy measures to the scales. With regard to the biology of CRF, the group identified the need for longitudinal research to examine biobehavioral mechanisms underlying CRF and testing mechanistic hypotheses within the context of intervention research. To address clinical trial issues, recommendations included using only placebo-controlled trial designs. setting eligibility to minimize sample heterogeneity or enable subgroup analysis, establishing a CRF severity threshold for participation in clinical trials, conducting dissemination trials of efficacious interventions (such as exercise), and combining nonpharmacologic and pharmacologic interventions to exploit the potential synergy between these approaches. Accomplishing these goals has the potential to advance the science of CRF and improve the clinical management of this troubling symptom.

References

  1. J Clin Oncol. 2008 Feb 20;26(6):907-12 - PubMed
  2. Health Qual Life Outcomes. 2007 Feb 27;5:12 - PubMed
  3. Support Care Cancer. 2005 Apr;13(4):246-54 - PubMed
  4. J Pain Symptom Manage. 2010 Mar;39(3):572-8 - PubMed
  5. J Clin Oncol. 2005 Sep 1;23(25):6097-106 - PubMed
  6. Psychooncology. 2009 Dec;18(12):1261-72 - PubMed
  7. Evid Based Complement Alternat Med. 2011;2011:623168 - PubMed
  8. Cancer. 2010 Dec 15;116(24):5740-8 - PubMed
  9. Support Care Cancer. 2012 Jun;20(6):1211-9 - PubMed
  10. Med Sci Sports Exerc. 2010 Jul;42(7):1409-26 - PubMed
  11. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD006145 - PubMed
  12. J Pain Symptom Manage. 2010 Jun;39(6):1086-99 - PubMed
  13. J Gerontol A Biol Sci Med Sci. 2004 Oct;59(10):1050-5 - PubMed
  14. Psychooncology. 2009 Jun;18(6):634-46 - PubMed
  15. Worldviews Evid Based Nurs. 2011 Dec;8(4):191-201 - PubMed
  16. J Clin Oncol. 2005 Sep 20;23(27):6613-22 - PubMed
  17. J Pain Symptom Manage. 2003 Apr;25(4):319-28 - PubMed
  18. Cancer Nurs. 2012 Jul-Aug;35(4):312-22 - PubMed
  19. Clin Oncol (R Coll Radiol). 2010 Apr;22(3):208-21 - PubMed
  20. Natl Cancer Inst Monogr. 1960 Aug;3:277-92 - PubMed
  21. Drug Discov Today Dis Models. 2011 Winter;8(4):167-173 - PubMed
  22. Cancer Causes Control. 2009 Oct;20(8):1523-8 - PubMed
  23. J Clin Oncol. 2001 Jul 15;19(14):3385-91 - PubMed
  24. J Natl Cancer Inst. 2008 Aug 20;100(16):1155-66 - PubMed
  25. Oncol Nurs Forum. 2010 Nov;37(6):E359-69 - PubMed
  26. J Pain Symptom Manage. 2010 Oct;40(4):483-94 - PubMed
  27. J Psychosom Res. 2011 Sep;71(3):117-23 - PubMed
  28. Psychooncology. 2011 Feb;20(2):115-26 - PubMed
  29. Int J Sports Med. 1997 Mar;18 Suppl 1:S91-100 - PubMed
  30. J Pediatr Hematol Oncol. 2008 Apr;30(4):272-80 - PubMed
  31. J Pediatr Hematol Oncol. 2007 Jul;29(7):471-9 - PubMed
  32. Sleep. 2012 Feb 01;35(2):237-45 - PubMed
  33. PM R. 2010 May;2(5):359-63 - PubMed
  34. J Pain Symptom Manage. 2007 Dec;34(6):607-18 - PubMed
  35. J Clin Oncol. 2006 May 1;24(13):2073-8 - PubMed
  36. J Am Coll Surg. 2012 Apr;214(4):463-75; discussion 475-7 - PubMed
  37. Breast Cancer Res Treat. 2008 Nov;112(1):5-13 - PubMed
  38. Eur J Cancer. 2008 Jan;44(2):175-81 - PubMed
  39. Oncol Nurs Forum. 2007 Sep;34(5):E51-9 - PubMed
  40. Eur J Cancer. 2010 Jul;46(10):1848-55 - PubMed
  41. J Psychosom Res. 2006 Jan;60(1):29-38 - PubMed
  42. J Clin Oncol. 2008 Oct 1;26(28):4651-8 - PubMed
  43. Brain Behav Immun. 2011 Oct;25(7):1376-83 - PubMed
  44. Psychoneuroendocrinology. 2005 Jan;30(1):92-100 - PubMed
  45. J Natl Compr Canc Netw. 2010 Aug;8(8):958-66 - PubMed
  46. Psychol Bull. 2008 Sep;134(5):700-741 - PubMed
  47. Support Care Cancer. 2010 Jan;18(1):105-14 - PubMed
  48. Palliat Med. 2006 Jun;20(4):413-8 - PubMed
  49. J Pain Symptom Manage. 2006 Sep;32(3):245-54 - PubMed
  50. J Pain Symptom Manage. 2007 Jul;34(1):94-104 - PubMed
  51. J Pediatr Oncol Nurs. 2011 Sep-Oct;28(5):287-94 - PubMed
  52. Eur J Cancer. 2006 May;42(7):846-63 - PubMed
  53. Eur J Oncol Nurs. 2009 Dec;13(5):399-408 - PubMed
  54. J Natl Compr Canc Netw. 2010 Aug;8(8):904-31 - PubMed
  55. Clin J Oncol Nurs. 2008 Oct;12(5 Suppl):27-36 - PubMed
  56. Gynecol Oncol. 2012 Apr;125(1):114-9 - PubMed
  57. Semin Oncol Nurs. 2007 May;23(2):99-105 - PubMed
  58. Brain Behav Immun. 2007 Oct;21(7):863-71 - PubMed
  59. Qual Life Res. 2013 Nov;22(9):2417-27 - PubMed
  60. Cancer. 2010 Jul 15;116(14):3513-20 - PubMed
  61. J Pain Symptom Manage. 2010 Oct;40(4):531-44 - PubMed
  62. Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):123-33 - PubMed
  63. Cancer. 2007 Nov 15;110(10):2321-30 - PubMed
  64. Clin J Oncol Nurs. 2012 Jun 1;16(3):293-300 - PubMed
  65. Appl Physiol Nutr Metab. 2011 Dec;36(6):892-903 - PubMed
  66. Oncology (Williston Park). 1998 Nov;12(11A):369-77 - PubMed
  67. J Pain Symptom Manage. 2008 Aug;36(2):191-9 - PubMed
  68. Oncologist. 2007;12 Suppl 1:22-34 - PubMed
  69. Brain Behav Immun. 2007 Feb;21(2):153-60 - PubMed
  70. Cancer. 2010 Jan 15;116(2):529-37 - PubMed
  71. J Support Oncol. 2012 Jan-Feb;10(1):14-24 - PubMed
  72. Cancer. 2012 Apr 15;118(8 Suppl):2261-9 - PubMed
  73. Cancer Nurs. 2008 Mar-Apr;31(2):134-44 - PubMed
  74. Psychooncology. 2007 May;16(5):437-47 - PubMed
  75. Oncol Nurs Forum. 2007 Sep;34(5):971-80 - PubMed
  76. J Natl Compr Canc Netw. 2008 May;6(5):448-55 - PubMed
  77. Onkologie. 2010;33(11):625-30 - PubMed
  78. Br J Cancer. 2008 Nov 4;99(9):1408-14 - PubMed
  79. Int Nurs Rev. 2008 Dec;55(4):412-9 - PubMed
  80. BMC Cancer. 2010 Jun 09;10:272 - PubMed
  81. J Psychosom Res. 2002 Jun;52(6):453-9 - PubMed
  82. Oncol Nurs Forum. 2011 May;38(3):E191-203 - PubMed
  83. Brain Behav Immun. 2009 Feb;23(2):149-58 - PubMed
  84. J Nurs Scholarsh. 2011 Sep;43(3):274-81 - PubMed
  85. Nat Sci Sleep. 2010 Dec 16;2:1-8 - PubMed
  86. Ann Oncol. 2009 Jan;20(1):17-25 - PubMed
  87. J Clin Oncol. 2009 Dec 10;27(35):6033-40 - PubMed
  88. Chronobiol Int. 2010 Jan;27(2):363-77 - PubMed
  89. J Natl Cancer Inst. 2009 Dec 2;101(23):1633-41 - PubMed
  90. Biol Res Nurs. 2009 Jul;11(1):27-41 - PubMed
  91. Pharmacogenomics J. 2009 Oct;9(5):333-40 - PubMed
  92. Sports Med. 2001 Feb;31(2):115-44 - PubMed
  93. Med Care. 1992 Jun;30(6):473-83 - PubMed
  94. Support Care Cancer. 2011 Oct;19(10):1581-91 - PubMed
  95. Oncologist. 2000;5(5):353-60 - PubMed
  96. Cancer Detect Prev. 2004;28(3):208-13 - PubMed
  97. Nat Rev Cancer. 2008 Nov;8(11):887-99 - PubMed
  98. Cancer Nurs. 2010 May-Jun;33(3):201-12 - PubMed
  99. Support Care Cancer. 2006 Mar;14(3):201-9 - PubMed
  100. Pediatr Blood Cancer. 2013 Mar;60(3):402-8 - PubMed
  101. Int J Cancer. 2012 Dec 1;131(11):2684-92 - PubMed
  102. Brain Behav Immun. 2007 May;21(4):413-27 - PubMed
  103. J Pediatr Oncol Nurs. 1998 Jul;15(3):172-82 - PubMed
  104. J Am Geriatr Soc. 2010 Feb;58(2):282-91 - PubMed
  105. Oncol Nurs Forum. 2008 Sep;35(5):802-7 - PubMed
  106. Oncologist. 2007;12 Suppl 1:11-21 - PubMed
  107. Support Care Cancer. 2009 Oct;17(10):1301-9 - PubMed
  108. Cancer. 2012 Aug 1;118(15):3766-75 - PubMed
  109. J Clin Oncol. 2008 Feb 20;26(6):971-82 - PubMed
  110. Med Care. 2007 May;45(5 Suppl 1):S3-S11 - PubMed
  111. Clin Cancer Res. 2009 Sep 1;15(17):5534-40 - PubMed
  112. Health Psychol. 2007 Nov;26(6):660-7 - PubMed
  113. Arch Phys Med Rehabil. 2011 Oct;92(10 Suppl):S20-7 - PubMed
  114. Clin Cancer Res. 2005 Mar 1;11(5):1757-64 - PubMed
  115. Sleep. 2009 Sep;32(9):1155-60 - PubMed
  116. Cancer. 2006 Feb 15;106(4):751-8 - PubMed
  117. J Clin Oncol. 2009 May 10;27(14):2396-404 - PubMed
  118. Cancer Prev Res (Phila). 2013 Feb;6(2):109-18 - PubMed
  119. J Pediatr Oncol Nurs. 2008 Mar-Apr;25(2):86-96 - PubMed
  120. Semin Hematol. 1997 Jul;34(3 Suppl 2):13-9 - PubMed
  121. J Pediatr Oncol Nurs. 2003 Jul-Aug;20(4):192-200 - PubMed
  122. Behav Sleep Med. 2012;10(3):217-29 - PubMed
  123. J Behav Med. 2012 Feb;35(1):86-94 - PubMed
  124. J Pain Symptom Manage. 2002 May;23(5):406-16 - PubMed
  125. J Clin Oncol. 2011 Sep 10;29(26):3517-22 - PubMed
  126. Semin Oncol Nurs. 2012 May;28(2):129-38 - PubMed
  127. Cancer Nurs. 2011 Jan-Feb;34(1):3-12 - PubMed
  128. J Clin Oncol. 2007 Nov 10;25(32):5106-12 - PubMed
  129. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD006953 - PubMed
  130. J Clin Oncol. 2013 May 1;31(13):1656-61 - PubMed
  131. Cancer Res. 2009 Jun 1;69(11):4700-7 - PubMed
  132. Integr Cancer Ther. 2009 Dec;8(4):387-97 - PubMed
  133. Eur J Cancer. 2009 Feb;45(3):384-92 - PubMed
  134. Pediatr Blood Cancer. 2007 Aug;49(2):160-5 - PubMed

Substances

MeSH terms

Publication Types

Grant support