Arch Pharm Res. 2013 Nov;36(11):1338-44. doi: 10.1007/s12272-013-0203-6. Epub 2013 Aug 06.

Synthesis and negative inotropic effects evaluation of 7-substituted-4,5-dihydro-[1,2,4]oxadiazolo[4,3-a]quinolin-1-ones.

Archives of pharmacal research

Lan Hong, Guo-Hua Gong, Li Yu, Ming-Xia Song, Xun Cui, Zhe-Shan Quan

PMID: 23918646 DOI: 10.1007/s12272-013-0203-6

Abstract

A series of 7-alkoxy-4,5-dihydro-[1,2,4]oxadiazolo[4,3-a]quinolin-1-ones was synthesized and their negative inotropic effects were evaluated by measuring the left atrium stroke volume in isolated rabbit heart preparations. All compounds moderated the cardiac workload by decreasing heart rate and contractility (inotropic effects). Among them, compound 6 was found to be best potent with a -28.89 ± 1.91 % decrease in the stroke volume at a concentration of 3 × 10(-5) M in our in vitro study.

Substances

• Quinolones

MeSH terms

• Animals
• Depression, Chemical
• In Vitro Techniques
• Molecular Structure
• Myocardial Contraction / drug effects
• Quinolones / chemical synthesis
• Quinolones / pharmacology
• Rabbits
• Stroke Volume / drug effects
• Structure-Activity Relationship

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't