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Davidson NO, Hausman AM, Ifkovits CA, et al. Human intestinal glucose transporter expression and localization of GLUT5. Am J Physiol. 1992;262(3):C795-800doi: 10.1152/ajpcell.1992.262.3.C795.
Davidson, N. O., Hausman, A. M., Ifkovits, C. A., Buse, J. B., Gould, G. W., Burant, C. F., & Bell, G. I. (1992). Human intestinal glucose transporter expression and localization of GLUT5. The American journal of physiology, 262(3), C795-800. https://doi.org/10.1152/ajpcell.1992.262.3.C795
Davidson, N O, et al. "Human intestinal glucose transporter expression and localization of GLUT5." The American journal of physiology vol. 262,3 (1992): C795-800. doi: https://doi.org/10.1152/ajpcell.1992.262.3.C795
Davidson NO, Hausman AM, Ifkovits CA, Buse JB, Gould GW, Burant CF, Bell GI. Human intestinal glucose transporter expression and localization of GLUT5. Am J Physiol. 1992 Mar;262(3):C795-800. doi: 10.1152/ajpcell.1992.262.3.C795. PMID: 1550217.
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Am J Physiol. 1992 Mar;262(3):C795-800. doi: 10.1152/ajpcell.1992.262.3.C795.

Human intestinal glucose transporter expression and localization of GLUT5.

The American journal of physiology

N O Davidson, A M Hausman, C A Ifkovits, J B Buse, G W Gould, C F Burant, G I Bell

Affiliations

  1. Department of Medicine, University of Chicago, Illinois 60637.

PMID: 1550217 DOI: 10.1152/ajpcell.1992.262.3.C795

Abstract

We have studied the developmental and regional expression of mRNAs encoding sodium-dependent and facilitative glucose transporter proteins in human fetal and adult small intestine. The abundance of mRNAs encoding the Na(+)-glucose cotransporter isoform SGLT1 and the facilitative glucose transporter isoforms GLUT2 and GLUT5 is developmentally modulated with highest levels in adult small intestine. By contrast, the levels of GLUT1 mRNA are higher in fetal than adult small intestine. Immunohistochemical analysis of adult small intestine localized GLUT5 to the luminal surface of mature enterocytes, a finding confirmed by Western blot analysis of purified human jejunal brush-border membranes. By contrast, in the fetal small intestine, GLUT5 was localized along the intercellular junctions of the developing villus, indicating that both its expression and localization are developmentally regulated. The localization of GLUT5 to the luminal surface of mature absorptive epithelial cells implies that this protein participates in the uptake of dietary sugars.

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