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Environ Geochem Health. 2014 Feb;36(1):55-64. doi: 10.1007/s10653-013-9518-y. Epub 2013 Apr 04.

The assessment of the malignant mesothelioma cases and environmental asbestos exposure in Sivas province, Turkey.

Environmental geochemistry and health

Serdar Berk, Huseyin Yalcin, Omer Tamer Dogan, Kursat Epozturk, Ibrahim Akkurt, Zehra Seyfikli

Affiliations

  1. Department of Chest Diseases, Faculty of Medicine, Cumhuriyet University, 58140, Sivas, Turkey, [email protected].

PMID: 23553125 DOI: 10.1007/s10653-013-9518-y

Abstract

One of the most significant diseases related to environmental asbestos exposure is malignant mesothelioma (MM). Sivas province is located in the Central Anatolia where asbestos exposure is common. We aimed to study clinical, demographical and epidemiologic features of the patients with MM in Sivas, along with the history of asbestos exposure. In total, 219 patients with MM who were diagnosed in our hospital between 1993 and 2010 were retrospectively analyzed in terms of demographical and clinical features. Rock, soil and house plaster samples were taken from the habitats of those patients and were evaluated with optical microscopy and X-ray diffraction methods. The age of the patients ranged between 18 and 85 years. The male-to-female ratio was 1.4:1. Most of the patients confirmed an asbestos exposure history. The most frequent symptoms of the patients were chest pain (60 %) and dyspnea (50 %). The gap between the start of first symptoms and the diagnosis date was approximately 4 months in average. The plaster materials used in most of the houses were made up of mainly carbonate and silicate minerals and some chrysotile. Ophiolitic units contained fibrous minerals such as serpentine (clino + orthochrysotile) chiefly and pectolite, brucite, hydrotalcite and tremolite/actinolite in smaller amounts. MM is not primarily related to occupational asbestos exposure in our region, and hence, environmental asbestos exposure may be indicted. Yet, single or combined roles and/or interactions of other fibrous and non-fibrous minerals in the etiology of MM are not yet fully understood and remain to be investigated.

References

  1. Semin Oncol. 2002 Feb;29(1):2-17 - PubMed
  2. Ann Occup Hyg. 2000 Dec;44(8):565-601 - PubMed
  3. Br J Ind Med. 1988 Dec;45(12):838-40 - PubMed
  4. Int J Hyg Environ Health. 2005;208(3):201-10 - PubMed
  5. Orphanet J Rare Dis. 2008 Dec 19;3:34 - PubMed
  6. J Occup Med. 1983 May;25(5):409-25 - PubMed
  7. Ann N Y Acad Sci. 1979;330:423-32 - PubMed
  8. Eur J Cancer. 2007 Dec;43(18):2722-8 - PubMed
  9. J Cancer Res Clin Oncol. 2009 Jan;135(1):15-27 - PubMed
  10. Chest. 2013 Jan;143(1):164-171 - PubMed
  11. Chest. 1992 Sep;102(3):790-6 - PubMed
  12. Br J Ind Med. 1960 Oct;17:260-71 - PubMed
  13. Cancer. 1988 Aug 15;62(4):838-47 - PubMed
  14. Curr Treat Options Oncol. 2008 Jun;9(2-3):147-57 - PubMed
  15. Respir Med. 1999 May;93(5):349-55 - PubMed
  16. Crit Rev Toxicol. 2006 Feb;36(2):165-87 - PubMed
  17. Chest. 1976 Jul;70(1):43-7 - PubMed
  18. Cancer Control. 2006 Oct;13(4):255-63 - PubMed
  19. Chest. 2002 Dec;122(6):2224-9 - PubMed
  20. MedGenMed. 2007 May 10;9(2):32 - PubMed
  21. Occup Environ Med. 2010 Nov;67(11):760-5 - PubMed
  22. J Occup Med. 1992 Jul;34(7):718-21 - PubMed
  23. Thorax. 1980 Aug;35(8):564-9 - PubMed

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