Display options
Cite
Blanche C, Czer LS, Trento A, et al. Bradyarrhythmias requiring pacemaker implantation after orthotopic heart transplantation: association with rejection. J Heart Lung Transplant. 1992;11(3):446-52
Blanche, C., Czer, L. S., Trento, A., Fishbein, M. C., Doan, D., Jordan, S., Utley, C. B., Barath, P., & Matloff, J. M. (1992). Bradyarrhythmias requiring pacemaker implantation after orthotopic heart transplantation: association with rejection. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 11(3), 446-52.
Blanche, C, et al. "Bradyarrhythmias requiring pacemaker implantation after orthotopic heart transplantation: association with rejection." The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation vol. 11,3 (1992): 446-52.
Blanche C, Czer LS, Trento A, Fishbein MC, Doan D, Jordan S, Utley CB, Barath P, Matloff JM. Bradyarrhythmias requiring pacemaker implantation after orthotopic heart transplantation: association with rejection. J Heart Lung Transplant. 1992 May-Jun;11(3):446-52. PMID: 1610853.
Copy Download .nbib Format: NLM
Share it on

J Heart Lung Transplant. 1992 May-Jun;11(3):446-52.

Bradyarrhythmias requiring pacemaker implantation after orthotopic heart transplantation: association with rejection.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

C Blanche, L S Czer, A Trento, M C Fishbein, D Doan, S Jordan, C B Utley, P Barath, J M Matloff

Affiliations

  1. Department of Thoracic and Cardiovascular Surgery, Cedars-Sinai Medical Center, Los Angeles, Calif 90048.

PMID: 1610853

Abstract

Patients with severe sinus-node dysfunction that required pacemaker implantation after orthotopic heart transplantation were reviewed. During a 21-month period, 42 transplantations were performed in 41 patients. Five patients (12.2%) required a permanent pacemaker because of severe dysrhythmias. Three patients had moderate-to-severe cellular and/or humoral (vascular) rejection, and two of the five patients (40%) died. In the remaining two patients, bradyarrhythmias were due most likely to trauma to the sinus node during harvesting of the donor heart, and these patients have shown no evidence of significant rejection on repeated biopsies. A strong relationship was found between moderate or severe rejection and the development of significant bradyarrhythmias that required the placement of a permanent pacemaker. The development of severe dysrhythmias during the early or late posttransplantation period should be considered a manifestation of an ongoing rejection episode until proven otherwise. In our experience this evidence of rejection may imply a poor prognostic sign because it is associated with high mortality rates.

Similar articles

Cited by

MeSH terms

Publication Types

LinkOut - more resources