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Liu JN, Lu L, Gao X, et al. The structural basis of the poor fibrin specificity of urokinase(I)--knowledge-based prediction of kringle structures of urokinase and its related proteins. Sci China B. 1992;35(2):176-82
Liu, J. N., Lu, L., Gao, X., Wang, J., Zhu, D. X., Lai, L. H., Xu, X. J., & Tang, Y. Q. (1992). The structural basis of the poor fibrin specificity of urokinase(I)--knowledge-based prediction of kringle structures of urokinase and its related proteins. Science in China. Series B, Chemistry, life sciences & earth sciences, 35(2), 176-82.
Liu, J N, et al. "The structural basis of the poor fibrin specificity of urokinase(I)--knowledge-based prediction of kringle structures of urokinase and its related proteins." Science in China. Series B, Chemistry, life sciences & earth sciences vol. 35,2 (1992): 176-82.
Liu JN, Lu L, Gao X, Wang J, Zhu DX, Lai LH, Xu XJ, Tang YQ. The structural basis of the poor fibrin specificity of urokinase(I)--knowledge-based prediction of kringle structures of urokinase and its related proteins. Sci China B. 1992 Feb;35(2):176-82. PMID: 1581002.
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Sci China B. 1992 Feb;35(2):176-82.

The structural basis of the poor fibrin specificity of urokinase(I)--knowledge-based prediction of kringle structures of urokinase and its related proteins.

Science in China. Series B, Chemistry, life sciences & earth sciences

J N Liu, L Lu, X Gao, J Wang, D X Zhu, L H Lai, X J Xu, Y Q Tang

Affiliations

  1. Department of Biochemistry, Nanjing University, PRC.

PMID: 1581002

Abstract

The Kringle-1 structure of plasminogen (PGK-1), the Kringle-2 structure of tissue plasminogen activator (PAK-2) and the Kringle structure of prourokinase (UKK) has been modeled on the basis of the three-dimensional structure of Kringle-1 of prothrombin (PTK-1) at 2.8 A resolution. The predicted three-dimensional structure of these Kringles shows that the binding site of PGK-1 is characterized by an apparent dipolar site, the polar parts of which are separated by a hydrophobic region. PAK-2 possesses the anionic center but has not a cationic binding center which might be provided by a guanidinium group from Arg-69 located adjacent to the Arg-71 position. UKK possesses neither the anionic binding center nor the cationic center which are probably the main reason for the poor fibrin specificity of urokinase.

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