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Bosn J Basic Med Sci. 2013 Feb;13(1):44-9. doi: 10.17305/bjbms.2013.2419.

Signaling prodromes of sudden cardiac death.

Bosnian journal of basic medical sciences

Ivana Vranic

Affiliations

  1. University Clinical Center of Serbia, Clinic for cardiosurgery, St. Koste Todorovic 8, 11000 Belgrade, Serbia. [email protected]

PMID: 23448610 PMCID: PMC4333928 DOI: 10.17305/bjbms.2013.2419

Abstract

The new criteria in detection of ARVC/D produced more subtle noninvasive parameters that raised sensitivity in diagnosis. Since heart rate dynamics have prognostic significance for the progression of a disease and for mortality, the main objective was to explore its value in disclosing risk for serious arrhythmias. Out of 100 ARVC/D patients, 35 with normal ECG Holter recordings (PVC<100) and no medical treatment (either antiarrhythmic or proarrhythmic drugs) were analyzed according to severity of ARVC/D (Group 1/mild, n=23 and Group 2/overt, n=12) and regarding positive late potentials (noise interval between 0.1-0.3 μV). Severity of ARVC/D is defined: group 1 with no clinical recognizable signs and group 2 with clinical readily recognizable signs. Group 3 (control) consisted of 35 randomly assigned healthy subjects. The differences between the 3 groups were assessed by ANOVA followed by Bonferroni`s post hoc multiple-range tests. NLD methods, as opposed to linear time and frequency, show very significant differences between investigated groups vs. control. NLD methods by mean of the standard deviations of all NN intervals of sinus beats for all 5-minute segments (SDNN index) showed prevalence of parasympathetic activity as opposed to control. This was even more obvious through interpolation of data as % of deviation of Mean NN interval in function % frequency (p<0.005). NLD methods describe complex rhythm fluctuations in ARVC/D patients that put insight at proarrhythmic potential of affected subjects. Furthermore, in combination with late potentials they improve recognizing hidden risks for serious arrhythmias.

References

  1. Curr Opin Cardiol. 2004 Jan;19(1):2-11 - PubMed
  2. Clin Exp Pharmacol Physiol. 2008 Sep;35(9):987-94 - PubMed
  3. Auton Neurosci. 2000 Dec 28;86(1-2):114-9 - PubMed
  4. Biol Res Nurs. 2004 Jan;5(3):211-21 - PubMed
  5. Cardiovasc Diabetol. 2010 Nov 25;9:78 - PubMed
  6. Jpn J Physiol. 1992;42(5):741-52 - PubMed
  7. Med Klin (Munich). 2010 Dec;105(12):858-70 - PubMed
  8. Int J Cardiol. 2012 Mar 8;155(2):273-8 - PubMed
  9. Bosn J Basic Med Sci. 2010 Aug;10(3):227-33 - PubMed
  10. Bull Exp Biol Med. 2010 Jul;149(1):10-3 - PubMed
  11. Eur J Appl Physiol. 2011 Jun;111(6):1017-26 - PubMed
  12. Int J Cardiol. 2010 May 28;141(2):122-31 - PubMed
  13. Cardiol J. 2010;17(3):219-29 - PubMed
  14. Biol Cybern. 1988;58(3):203-11 - PubMed
  15. Circulation. 1996 Mar 1;93(5):1043-65 - PubMed
  16. Proc Natl Acad Sci U S A. 2002 Feb 19;99 Suppl 1:2466-72 - PubMed
  17. Braz J Med Biol Res. 2011 Jan;44(1):38-45 - PubMed
  18. Auton Neurosci. 2011 Feb 24;160(1-2):107-14 - PubMed
  19. Clin Auton Res. 2011 Feb;21(1):47-54 - PubMed
  20. Cardiovasc Res. 1996 Mar;31(3):419-33 - PubMed
  21. COPD. 2010 Dec;7(6):391-7 - PubMed
  22. Acta Anaesthesiol Scand. 2011 Feb;55(2):234-41 - PubMed
  23. Res Sports Med. 2010 Oct;18(4):263-9 - PubMed
  24. Rev Bras Cir Cardiovasc. 2009 Apr-Jun;24(2):205-17 - PubMed
  25. Int J Cardiol. 2012 May 3;156(3):259-64 - PubMed
  26. Stroke. 2011 Feb;42(2):491-3 - PubMed
  27. Nat Clin Pract Cardiovasc Med. 2008 Aug;5 Suppl 2:S79-86 - PubMed

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