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Hufford CD, el-Sharkawy SH, Jurgens TM, et al. Microbial production of a crisnatol metabolite. Pharm Res. 1992;9(5):623-5doi: 10.1023/a:1015893808830.
Hufford, C. D., el-Sharkawy, S. H., Jurgens, T. M., & Mikell, J. R. (1992). Microbial production of a crisnatol metabolite. Pharmaceutical research, 9(5), 623-5. https://doi.org/10.1023/a:1015893808830
Hufford, C D, et al. "Microbial production of a crisnatol metabolite." Pharmaceutical research vol. 9,5 (1992): 623-5. doi: https://doi.org/10.1023/a:1015893808830
Hufford CD, el-Sharkawy SH, Jurgens TM, Mikell JR. Microbial production of a crisnatol metabolite. Pharm Res. 1992 May;9(5):623-5. doi: 10.1023/a:1015893808830. PMID: 1608892.
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Pharm Res. 1992 May;9(5):623-5. doi: 10.1023/a:1015893808830.

Microbial production of a crisnatol metabolite.

Pharmaceutical research

C D Hufford, S H el-Sharkawy, T M Jurgens, J R Mikell

Affiliations

  1. Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University 38677.

PMID: 1608892 DOI: 10.1023/a:1015893808830

Abstract

Microbial metabolism studies of crisnatol (1), a new DNA intercalator, has resulted in the isolation and characterization of a major metabolite identified as the C-1 hydroxylated crisnatol (2). The structure of the metabolite was established by comparison of its spectral data to that of crisnatol. Complete 13C-NMR assignments for crisnatol and its C-1 hydroxylated metabolite were also made.

References

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  2. Drug Metab Dispos. 1991 Mar-Apr;19(2):491-7 - PubMed
  3. Med Res Rev. 1991 Sep;11(5):473-501 - PubMed
  4. Pharm Res. 1990 Sep;7(9):923-7 - PubMed
  5. Med Res Rev. 1985 Apr-Jun;5(2):231-53 - PubMed

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