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Patrick CC, Plaunt MR, Hetherington SV, et al. Role of the Staphylococcus epidermidis slime layer in experimental tunnel tract infections. Infect Immun. 1992;60(4):1363-7doi: 10.1128/iai.60.4.1363-1367.1992.
Patrick, C. C., Plaunt, M. R., Hetherington, S. V., & May, S. M. (1992). Role of the Staphylococcus epidermidis slime layer in experimental tunnel tract infections. Infection and immunity, 60(4), 1363-7. https://doi.org/10.1128/iai.60.4.1363-1367.1992
Patrick, C C, et al. "Role of the Staphylococcus epidermidis slime layer in experimental tunnel tract infections." Infection and immunity vol. 60,4 (1992): 1363-7. doi: https://doi.org/10.1128/iai.60.4.1363-1367.1992
Patrick CC, Plaunt MR, Hetherington SV, May SM. Role of the Staphylococcus epidermidis slime layer in experimental tunnel tract infections. Infect Immun. 1992 Apr;60(4):1363-7. doi: 10.1128/iai.60.4.1363-1367.1992. PMID: 1548062; PMCID: PMC257005.
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Atypon Free PMC Article

Infect Immun. 1992 Apr;60(4):1363-7. doi: 10.1128/iai.60.4.1363-1367.1992.

Role of the Staphylococcus epidermidis slime layer in experimental tunnel tract infections.

Infection and immunity

C C Patrick, M R Plaunt, S V Hetherington, S M May

Affiliations

  1. Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee.

PMID: 1548062 PMCID: PMC257005 DOI: 10.1128/iai.60.4.1363-1367.1992
Free PMC Article

Abstract

An experimental animal model was used to assess the slime layer of Staphylococcus epidermidis as a pathogenic factor in tunnel tract infections. Mice were inoculated with high-slime-producing or non-slime-producing strains of S. epidermidis, either along the length of a subcutaneous catheter or in the area where a catheter had been placed and immediately removed (controls). Among the catheter-bearing mice, the phenotypically distinct staphylococci produced similar, high frequencies of abscess formation (72% [44 of 61] versus 81% [31 of 38]; P = 0.29). In controls, the non-slime-producing organisms were significantly more pathogenic (87% [40 of 46] versus 57% [25 of 44] abscess formation; P = 0.001). No consistent difference was detected between blood isolates obtained from patients with central venous catheter bacteremia and those from neonates with bacteremia in the absence of a prosthetic medical device. Quantitative culture of removed catheters showed greater adherence by the slime-producing isolates (P = 0.014). In this mouse model, slime production by S. epidermidis did not increase the risk of catheter tunnel tract infection, despite the greater catheter adherence of the slime-producing organisms. These findings suggest that traumatized tissue may be a sufficient condition for the development of S. epidermidis catheter-associated infections.

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