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Hainsworth PJ, Raphael KL, Stillwell RG, et al. Rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features. Br J Cancer. 1992;66(1):131-5doi: 10.1038/bjc.1992.229.
Hainsworth, P. J., Raphael, K. L., Stillwell, R. G., Bennett, R. C., & Garson, O. M. (1992). Rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features. British journal of cancer, 66(1), 131-5. https://doi.org/10.1038/bjc.1992.229
Hainsworth, P J, et al. "Rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features." British journal of cancer vol. 66,1 (1992): 131-5. doi: https://doi.org/10.1038/bjc.1992.229
Hainsworth PJ, Raphael KL, Stillwell RG, Bennett RC, Garson OM. Rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features. Br J Cancer. 1992 Jul;66(1):131-5. doi: 10.1038/bjc.1992.229. PMID: 1637662; PMCID: PMC1977890.
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Nature Publishing Group Free PMC Article

Br J Cancer. 1992 Jul;66(1):131-5. doi: 10.1038/bjc.1992.229.

Rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features.

British journal of cancer

P J Hainsworth, K L Raphael, R G Stillwell, R C Bennett, O M Garson

Affiliations

  1. University of Melbourne Department of Surgery, St. Vincent's Hospital, Victoria, Australia.

PMID: 1637662 PMCID: PMC1977890 DOI: 10.1038/bjc.1992.229
Free PMC Article

Abstract

In a cytogenetic study of breast cancer biopsies, clonal abnormalities of chromosome 1p were identified in 56% (14) of 25 informative patients. Translocations predominated, involving 1p22 (n = 1), 1p35 (n = 1) or 1p36 (n = 10) breakpoints. Chromosome 1p abnormalities were associated with estrogen receptor (ER) negativity (P = 0.03, 2-tailed Fisher Exact Probability test), high histological grade (P = 0.02, 2-tailed Mann-Whitney U-test) and an unfavourable Melbourne Prognostic Score (NEPA P = 0.02, SEPA P = 0.04, 2-tailed Mann-Whitney U-tests). These findings are consistent with the possibility that a gene located on chromosome 1p is implicated in tumour progression.

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