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Påhlman S, Hammerling U. src expression in small-cell lung carcinoma and other neuroendocrine malignancies. Am Rev Respir Dis. 1990;142(6):S54-6doi: 10.1164/ajrccm/142.6_Pt_2.S54.
Påhlman, S., & Hammerling, U. (1990). src expression in small-cell lung carcinoma and other neuroendocrine malignancies. The American review of respiratory disease, 142(6), S54-6. https://doi.org/10.1164/ajrccm/142.6_Pt_2.S54
Påhlman, S, and Hammerling, U. "src expression in small-cell lung carcinoma and other neuroendocrine malignancies." The American review of respiratory disease vol. 142,6 (1990): S54-6. doi: https://doi.org/10.1164/ajrccm/142.6_Pt_2.S54
Påhlman S, Hammerling U. src expression in small-cell lung carcinoma and other neuroendocrine malignancies. Am Rev Respir Dis. 1990 Dec;142(6):S54-6. doi: 10.1164/ajrccm/142.6_Pt_2.S54. PMID: 2174663.
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Am Rev Respir Dis. 1990 Dec;142(6):S54-6. doi: 10.1164/ajrccm/142.6_Pt_2.S54.

src expression in small-cell lung carcinoma and other neuroendocrine malignancies.

The American review of respiratory disease

S Påhlman, U Hammerling

Affiliations

  1. Department of Pathology, University of Uppsala, Sweden.

PMID: 2174663 DOI: 10.1164/ajrccm/142.6_Pt_2.S54

Abstract

The proto-oncogene c-src codes for two tyrosine kinases, pp60c-src and pp60c-srcN. The latter protein appears to be exclusively expressed in neurons and neuronally differentiated tumors. In cell lines derived from neuroblastoma and small-cell lung carcinoma, src expression correlates positively with neuroendocrine differentiation. However, pp60c-srcN is expressed only in highly differentiated neuroblastomas. Although c-src expression in neuroendocrine tumors probably reflects and is the result of the differentiation stage at which the tumors have been arrested, high c-src expression and kinase activities in non-neuroectodermal tumors, e.g., colon carcinoma, breast carcinoma, might instead be a part of the malignant phenotype and contribute to the development of these tumors.

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