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Deng DD, Gong YL, Shou GF, et al. Simulation of biatrial conduction via different pathways during sinus rhythm with a detailed human atrial model. J Zhejiang Univ Sci B. 2012;13(9):676-94doi: 10.1631/jzus.B1100339.
Deng, D. D., Gong, Y. L., Shou, G. F., Jiao, P. F., Zhang, H. G., Ye, X. S., & Xia, L. (2012). Simulation of biatrial conduction via different pathways during sinus rhythm with a detailed human atrial model. Journal of Zhejiang University. Science. B, 13(9), 676-94. https://doi.org/10.1631/jzus.B1100339
Deng, Dong-dong, et al. "Simulation of biatrial conduction via different pathways during sinus rhythm with a detailed human atrial model." Journal of Zhejiang University. Science. B vol. 13,9 (2012): 676-94. doi: https://doi.org/10.1631/jzus.B1100339
Deng DD, Gong YL, Shou GF, Jiao PF, Zhang HG, Ye XS, Xia L. Simulation of biatrial conduction via different pathways during sinus rhythm with a detailed human atrial model. J Zhejiang Univ Sci B. 2012 Sep;13(9):676-94. doi: 10.1631/jzus.B1100339. PMID: 22949359; PMCID: PMC3437366.
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J Zhejiang Univ Sci B. 2012 Sep;13(9):676-94. doi: 10.1631/jzus.B1100339.

Simulation of biatrial conduction via different pathways during sinus rhythm with a detailed human atrial model.

Journal of Zhejiang University. Science. B

Dong-dong Deng, Ying-lan Gong, Guo-fa Shou, Pei-feng Jiao, Heng-gui Zhang, Xue-song Ye, Ling Xia

Affiliations

  1. College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China.

PMID: 22949359 PMCID: PMC3437366 DOI: 10.1631/jzus.B1100339

Abstract

In order to better understand biatrial conduction, investigate various conduction pathways, and compare the differences between isotropic and anisotropic conductions in human atria, we present a simulation study of biatrial conduction with known/assumed conduction pathways using a recently developed human atrial model. In addition to known pathways: (1) Bachmann's bundle (BB), (2) limbus of fossa ovalis (LFO), and (3) coronary sinus (CS), we also hypothesize that there exist two fast conduction bundles that connect the crista terminalis (CT), LFO, and CS. Our simulation demonstrates that use of these fast conduction bundles results in a conduction pattern consistent with experimental data. The comparison of isotropic and anisotropoic conductions in the BB case showed that the atrial working muscles had small effect on conduction time and conduction speed, although the conductivities assigned in anisotropic conduction were two to four times higher than the isotropic conduction. In conclusion, we suggest that the hypothesized intercaval bundles play a significant role in the biatrial conduction and that myofiber orientation has larger effects on the conduction system than the atrial working muscles. This study presents readers with new insights into human atrial conduction.

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