J Pharmacobiodyn. 1990 Nov;13(11):672-80. doi: 10.1248/bpb1978.13.672.

The acetylcholine-hypersensitive model of diabetic KK-CA(y) mice analyzed with pulse rate, and modified by repeated cold stress and by adrenalectomy.

Journal of pharmacobio-dynamics

I Kimura, T Matsui, M Kimura

PMID: 2093125 DOI: 10.1248/bpb1978.13.672

Abstract

The effects of acetylcholine on pulse rate were examined in the conscious state of diabetic KK-CA(y) male mice. By subcutaneously-administered acetylcholine at 3 and 10 mg/kg the pulse rate was increased in the prediabetic state, whereas it was decreased in the diabetic state. The acetylcholine-induced responses in pulse rate were significantly and multiply correlated with both the blood glucose level and the dose of acetylcholine in KK-CA(y) mice (r = 0.47, p less than 0.01). The diabetic state and adrenalectomy produced an acetylcholine-hypersensitive syndrome, respectively. The hypersensitivity to acetylcholine in a whole body of diabetic mice was attenuated by repeated cold stress producing acetylcholine-subsensitivity, and was enhanced by adrenalectomy. The diabetic KK-CA(y) mice are an acetylcholine-hypersensitive animal model.

Substances

• Blood Glucose
• Acetylcholine
• Norepinephrine

MeSH terms

• Acetylcholine / pharmacology
• Adrenal Glands / physiology
• Adrenalectomy
• Animals
• Autonomic Nervous System / physiopathology
• Blood Glucose / metabolism
• Blood Pressure / drug effects
• Cold Temperature
• Diabetes Mellitus, Experimental / complications
• Diabetes Mellitus, Experimental / physiopathology
• Dose-Response Relationship, Drug
• Male
• Mice
• Mice, Inbred Strains
• Norepinephrine / pharmacology
• Prediabetic State / physiopathology
• Pulse / drug effects
• Stress, Physiological / complications
• Stress, Physiological / physiopathology

Publication Types

• Journal Article