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Zaizen Y, Ford EG, Costin G, et al. The effect of perioperative exogenous growth hormone on wound bursting strength in normal and malnourished rats. J Pediatr Surg. 1990;25(1):70-4doi: 10.1016/s0022-3468(05)80166-6.
Zaizen, Y., Ford, E. G., Costin, G., & Atkinson, J. B. (1990). The effect of perioperative exogenous growth hormone on wound bursting strength in normal and malnourished rats. Journal of pediatric surgery, 25(1), 70-4. https://doi.org/10.1016/s0022-3468(05)80166-6
Zaizen, Y, et al. "The effect of perioperative exogenous growth hormone on wound bursting strength in normal and malnourished rats." Journal of pediatric surgery vol. 25,1 (1990): 70-4. doi: https://doi.org/10.1016/s0022-3468(05)80166-6
Zaizen Y, Ford EG, Costin G, Atkinson JB. The effect of perioperative exogenous growth hormone on wound bursting strength in normal and malnourished rats. J Pediatr Surg. 1990 Jan;25(1):70-4. doi: 10.1016/s0022-3468(05)80166-6. PMID: 2299548.
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J Pediatr Surg. 1990 Jan;25(1):70-4. doi: 10.1016/s0022-3468(05)80166-6.

The effect of perioperative exogenous growth hormone on wound bursting strength in normal and malnourished rats.

Journal of pediatric surgery

Y Zaizen, E G Ford, G Costin, J B Atkinson

Affiliations

  1. Division of Pediatric Surgery, Childrens Hospital, Los Angeles, CA 90027.

PMID: 2299548 DOI: 10.1016/s0022-3468(05)80166-6

Abstract

Patients with significant malnutrition secondary to underlying disease may require major surgical intervention on an urgent basis. Nutritional restoration using enteral or intravenous alimentation requires a delay of 10 to 14 days and is frequently not practical. With the availability of human growth hormone (GH) produced by recombinant DNA technology, this study was undertaken to evaluate the effect of exogenous GH on wound tensile strength in a rat model. Fifty-four animals were divided into three groups: group I, normal nourished control; group II, malnourished; group III, malnourished, rat GH treated (1 mg GH administered 3 days preoperative and 5 days postoperative celiotomy). Wound tensile strength was measured at 6 days postoperatively. Wound strengths in malnourished rats were significantly less than in normal controls (P less than .001). With the administration of growth hormone in group III, wound strength was significantly improved when slightly improved over normally nourished controls (P less than .05). A dose response curve demonstrated progressive improvement in wound tensile strength from 0.01 mg/d to 1.0 mg/d. Thus growth hormone administration to malnourished animals significantly enhances wound strength. With the availability of recombinant produced human GH these observations may be clinically applicable.

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